Functional improvement of dystrophic muscle by repression of utrophin: let-7c interaction.

Functional improvement of dystrophic muscle by repression of utrophin: let-7c interaction.

Duchenne muscular dystrophy (DMD) is a fatal genetic disease caused by an absence of the 427kD muscle-specific dystrophin isoform. Utrophin is the autosomal homolog of dystrophin and when overexpressed, can compensate for the absence of dystrophin and rescue the dystrophic phenotype of the mdx mouse...

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Bibliographic Details
Main Authors: Manoj K Mishra, Emanuele Loro, Kasturi Sengupta, Steve D Wilton, Tejvir S Khurana
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5646768?pdf=render

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