SARS-CoV-2 IgG Levels Allow Predicting the Optimal Time Span of Convalescent Plasma Donor Suitability
Convalescent plasma (CP) has been in use for the treatment of numerous infectious diseases for more than a century, recently also for coronavirus disease 2019 (COVID-19). A major challenge for this treatment is identifying suitable donors with sufficient levels of functional antibodies and to determ...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/11/2567 |
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| author | Sandra Laner-Plamberger Nadja Lindlbauer Lisa Weidner Simon Gänsdorfer Lukas Weseslindtner Nina Held Wanda Lauth Georg Zimmermann Jan Marco Kern Fabian Föttinger Laura Ombres Christof Jungbauer Eva Rohde Christoph Grabmer |
| author_facet | Sandra Laner-Plamberger Nadja Lindlbauer Lisa Weidner Simon Gänsdorfer Lukas Weseslindtner Nina Held Wanda Lauth Georg Zimmermann Jan Marco Kern Fabian Föttinger Laura Ombres Christof Jungbauer Eva Rohde Christoph Grabmer |
| author_sort | Sandra Laner-Plamberger |
| collection | DOAJ |
| description | Convalescent plasma (CP) has been in use for the treatment of numerous infectious diseases for more than a century, recently also for coronavirus disease 2019 (COVID-19). A major challenge for this treatment is identifying suitable donors with sufficient levels of functional antibodies and to determine the optimal time span for CP donation. In this retrospective study, we analyzed 189 CP donations of 66 donors regarding anti-SARS-CoV-2 anti-S IgG antibody levels. We found a significant correlation between the semi-quantitative SARS-CoV-2 IgG ratio values and in vitro antibody functionality. A time-to-event analysis allowed us to predict the optimal time span of COVID-19 CP donor suitability. We found that high IgG ratio values, which significantly correlate with high in vitro antibody functionality, were suitable for CP donation for a median of 134 days after the first CP donation. Donors with lower IgG ratios were suitable for a median of 53 days. Our data support plasma collection centers to determine optimal points in time for CP donation by means of widely used semi-quantitative laboratory IgG ratio values. |
| first_indexed | 2024-03-09T19:08:59Z |
| format | Article |
| id | doaj.art-089a1b07db5d44ca83acf3f9c85d758c |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T19:08:59Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-089a1b07db5d44ca83acf3f9c85d758c2023-11-24T04:17:21ZengMDPI AGDiagnostics2075-44182022-10-011211256710.3390/diagnostics12112567SARS-CoV-2 IgG Levels Allow Predicting the Optimal Time Span of Convalescent Plasma Donor SuitabilitySandra Laner-Plamberger0Nadja Lindlbauer1Lisa Weidner2Simon Gänsdorfer3Lukas Weseslindtner4Nina Held5Wanda Lauth6Georg Zimmermann7Jan Marco Kern8Fabian Föttinger9Laura Ombres10Christof Jungbauer11Eva Rohde12Christoph Grabmer13Department for Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University Salzburg, Müllner-Hauptstraße 48, 5020 Salzburg, AustriaDepartment for Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University Salzburg, Müllner-Hauptstraße 48, 5020 Salzburg, AustriaAustrian Red Cross, Blood Service for Vienna, Lower Austria and Burgenland, Wiedner Hauptstraße 32, 1040 Vienna, AustriaAustrian Red Cross, Blood Service for Vienna, Lower Austria and Burgenland, Wiedner Hauptstraße 32, 1040 Vienna, AustriaDepartment for Virology, Medical University Vienna, Kinderspitalgasse 15, 1090 Vienna, AustriaDepartment for Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University Salzburg, Müllner-Hauptstraße 48, 5020 Salzburg, AustriaTeam Biostatistics and Big Medical Data, IDA Lab Salzburg, Paracelsus Medical University Salzburg, Strubergasse 16, 5020 Salzburg, AustriaTeam Biostatistics and Big Medical Data, IDA Lab Salzburg, Paracelsus Medical University Salzburg, Strubergasse 16, 5020 Salzburg, AustriaDepartment for Clinical Microbiology and Hygiene, University Hospital of Salzburg, Paracelsus Medical University Salzburg, Müllner-Hauptstraße 48, 5020 Salzburg, AustriaDepartment for Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University Salzburg, Müllner-Hauptstraße 48, 5020 Salzburg, AustriaDepartment for Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University Salzburg, Müllner-Hauptstraße 48, 5020 Salzburg, AustriaAustrian Red Cross, Blood Service for Vienna, Lower Austria and Burgenland, Wiedner Hauptstraße 32, 1040 Vienna, AustriaDepartment for Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University Salzburg, Müllner-Hauptstraße 48, 5020 Salzburg, AustriaDepartment for Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University Salzburg, Müllner-Hauptstraße 48, 5020 Salzburg, AustriaConvalescent plasma (CP) has been in use for the treatment of numerous infectious diseases for more than a century, recently also for coronavirus disease 2019 (COVID-19). A major challenge for this treatment is identifying suitable donors with sufficient levels of functional antibodies and to determine the optimal time span for CP donation. In this retrospective study, we analyzed 189 CP donations of 66 donors regarding anti-SARS-CoV-2 anti-S IgG antibody levels. We found a significant correlation between the semi-quantitative SARS-CoV-2 IgG ratio values and in vitro antibody functionality. A time-to-event analysis allowed us to predict the optimal time span of COVID-19 CP donor suitability. We found that high IgG ratio values, which significantly correlate with high in vitro antibody functionality, were suitable for CP donation for a median of 134 days after the first CP donation. Donors with lower IgG ratios were suitable for a median of 53 days. Our data support plasma collection centers to determine optimal points in time for CP donation by means of widely used semi-quantitative laboratory IgG ratio values.https://www.mdpi.com/2075-4418/12/11/2567plasmapheresisconvalescent plasmaCOVID-19SARS-CoV-2 antibodies |
| spellingShingle | Sandra Laner-Plamberger Nadja Lindlbauer Lisa Weidner Simon Gänsdorfer Lukas Weseslindtner Nina Held Wanda Lauth Georg Zimmermann Jan Marco Kern Fabian Föttinger Laura Ombres Christof Jungbauer Eva Rohde Christoph Grabmer SARS-CoV-2 IgG Levels Allow Predicting the Optimal Time Span of Convalescent Plasma Donor Suitability Diagnostics plasmapheresis convalescent plasma COVID-19 SARS-CoV-2 antibodies |
| title | SARS-CoV-2 IgG Levels Allow Predicting the Optimal Time Span of Convalescent Plasma Donor Suitability |
| title_full | SARS-CoV-2 IgG Levels Allow Predicting the Optimal Time Span of Convalescent Plasma Donor Suitability |
| title_fullStr | SARS-CoV-2 IgG Levels Allow Predicting the Optimal Time Span of Convalescent Plasma Donor Suitability |
| title_full_unstemmed | SARS-CoV-2 IgG Levels Allow Predicting the Optimal Time Span of Convalescent Plasma Donor Suitability |
| title_short | SARS-CoV-2 IgG Levels Allow Predicting the Optimal Time Span of Convalescent Plasma Donor Suitability |
| title_sort | sars cov 2 igg levels allow predicting the optimal time span of convalescent plasma donor suitability |
| topic | plasmapheresis convalescent plasma COVID-19 SARS-CoV-2 antibodies |
| url | https://www.mdpi.com/2075-4418/12/11/2567 |
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