“Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review
ObjectivesThe aim of this systematic review was to summarize the available literature on gut microbiome (GMB) and osteoarthritis (OA), analyze the correlation between GMB and OA, and explore potential underlying mechanisms.MethodsA systematic search of the PubMed, Embase, Cochrane, and Web of Scienc...
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| Format: | Article |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1150572/full |
| _version_ | 1797839641085214720 |
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| author | Su Liu Su Liu Guoqing Li Guoqing Li Huihui Xu Huihui Xu Qichang Wang Qichang Wang Yihao Wei Yihao Wei Qi Yang Ao Xiong Ao Xiong Fei Yu Fei Yu Jian Weng Jian Weng Hui Zeng Hui Zeng |
| author_facet | Su Liu Su Liu Guoqing Li Guoqing Li Huihui Xu Huihui Xu Qichang Wang Qichang Wang Yihao Wei Yihao Wei Qi Yang Ao Xiong Ao Xiong Fei Yu Fei Yu Jian Weng Jian Weng Hui Zeng Hui Zeng |
| author_sort | Su Liu |
| collection | DOAJ |
| description | ObjectivesThe aim of this systematic review was to summarize the available literature on gut microbiome (GMB) and osteoarthritis (OA), analyze the correlation between GMB and OA, and explore potential underlying mechanisms.MethodsA systematic search of the PubMed, Embase, Cochrane, and Web of Science with the keywords “Gut Microbiome” and “Osteoarthritis” was conducted to identify the human and animal studies exploring the association between GMB and OA. The retrieval time range was from the database inception to July 31, 2022. Studies reported the other arthritic diseases without OA, reviews, and studies focused on the microbiome in other parts of the body with OA, such as oral or skin, were excluded. The included studies were mainly reviewed for GMB composition, OA severity, inflammatory factors, and intestinal permeability.ResultsThere were 31 studies published met the inclusion criteria and were analyzed, including 10 human studies and 21 animal studies. Human and animal studies have reached a consistent conclusion that GMB dysbiosis could aggravate OA. In addition, several studies have found that alterations of GMB composition can increase intestinal permeability and serum levels of inflammatory factors, while regulating GMB can alleviate the changes. Owing to the susceptibility of GMB to internal and external environments, genetics, and geography, the included studies were not consistent in GMB composition analysis.ConclusionThere is a lack of high-quality studies evaluating the effects of GMB on OA. Available evidence indicated that GMB dysbiosis aggravated OA through activating the immune response and subsequent induction of inflammation. Future studies should focus on more prospective, cohort studies combined with multi-omics to further clarify the correlation. |
| first_indexed | 2024-04-09T16:01:23Z |
| format | Article |
| id | doaj.art-089a256ded7d48b48b3074f0a2834c9c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T16:01:23Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-089a256ded7d48b48b3074f0a2834c9c2023-04-25T10:08:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-04-011410.3389/fimmu.2023.11505721150572“Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic reviewSu Liu0Su Liu1Guoqing Li2Guoqing Li3Huihui Xu4Huihui Xu5Qichang Wang6Qichang Wang7Yihao Wei8Yihao Wei9Qi Yang10Ao Xiong11Ao Xiong12Fei Yu13Fei Yu14Jian Weng15Jian Weng16Hui Zeng17Hui Zeng18Department of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, ChinaNational and Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, ChinaDepartment of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, ChinaNational and Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, ChinaDepartment of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, ChinaNational and Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, ChinaDepartment of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, ChinaNational and Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, ChinaDepartment of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, ChinaNational and Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, ChinaDepartment of Ultrasonography, Peking University Shenzhen Hospital, Shenzhen, ChinaDepartment of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, ChinaNational and Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, ChinaDepartment of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, ChinaNational and Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, ChinaDepartment of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, ChinaNational and Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, ChinaDepartment of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, ChinaNational and Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, ChinaObjectivesThe aim of this systematic review was to summarize the available literature on gut microbiome (GMB) and osteoarthritis (OA), analyze the correlation between GMB and OA, and explore potential underlying mechanisms.MethodsA systematic search of the PubMed, Embase, Cochrane, and Web of Science with the keywords “Gut Microbiome” and “Osteoarthritis” was conducted to identify the human and animal studies exploring the association between GMB and OA. The retrieval time range was from the database inception to July 31, 2022. Studies reported the other arthritic diseases without OA, reviews, and studies focused on the microbiome in other parts of the body with OA, such as oral or skin, were excluded. The included studies were mainly reviewed for GMB composition, OA severity, inflammatory factors, and intestinal permeability.ResultsThere were 31 studies published met the inclusion criteria and were analyzed, including 10 human studies and 21 animal studies. Human and animal studies have reached a consistent conclusion that GMB dysbiosis could aggravate OA. In addition, several studies have found that alterations of GMB composition can increase intestinal permeability and serum levels of inflammatory factors, while regulating GMB can alleviate the changes. Owing to the susceptibility of GMB to internal and external environments, genetics, and geography, the included studies were not consistent in GMB composition analysis.ConclusionThere is a lack of high-quality studies evaluating the effects of GMB on OA. Available evidence indicated that GMB dysbiosis aggravated OA through activating the immune response and subsequent induction of inflammation. Future studies should focus on more prospective, cohort studies combined with multi-omics to further clarify the correlation.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1150572/fullgut microbiomeosteoarthritiscartilageinflammationimmune response |
| spellingShingle | Su Liu Su Liu Guoqing Li Guoqing Li Huihui Xu Huihui Xu Qichang Wang Qichang Wang Yihao Wei Yihao Wei Qi Yang Ao Xiong Ao Xiong Fei Yu Fei Yu Jian Weng Jian Weng Hui Zeng Hui Zeng “Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review Frontiers in Immunology gut microbiome osteoarthritis cartilage inflammation immune response |
| title | “Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review |
| title_full | “Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review |
| title_fullStr | “Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review |
| title_full_unstemmed | “Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review |
| title_short | “Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review |
| title_sort | cross talk between gut microbiome dysbiosis and osteoarthritis progression a systematic review |
| topic | gut microbiome osteoarthritis cartilage inflammation immune response |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1150572/full |
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