Opportunities and challenges of mRNA technologies in development of dengue virus vaccine
Dengue virus (DENV) is a mosquito-borne virus with a significant human health concern. With 390 million infections annually and 96 million showing clinical symptoms, severe dengue can lead to life-threatening conditions like dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). The only FD...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-03-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1520968/full |
| _version_ | 1826550381928251392 |
|---|---|
| author | Xiaoyang Liu |
| author_facet | Xiaoyang Liu |
| author_sort | Xiaoyang Liu |
| collection | DOAJ |
| description | Dengue virus (DENV) is a mosquito-borne virus with a significant human health concern. With 390 million infections annually and 96 million showing clinical symptoms, severe dengue can lead to life-threatening conditions like dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). The only FDA-approved vaccine, Dengvaxia, has limitations due to antibody-dependent enhancement (ADE), necessitating careful administration. The recent pre-approval of TAK-003 by WHO in 2024 highlights ongoing efforts to improve vaccine options. This review explores recent advancements in dengue vaccine development, emphasizing potential utility of mRNA-based vaccines. By examining current clinical trial data and innovations, we aim to identify promising strategies to address the limitations of existing vaccines and enhance global dengue prevention efforts. |
| first_indexed | 2025-03-14T06:36:26Z |
| format | Article |
| id | doaj.art-089a745f833d4aed851e59388e69756f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2025-03-14T06:36:26Z |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-089a745f833d4aed851e59388e69756f2025-03-05T07:07:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-03-011610.3389/fimmu.2025.15209681520968Opportunities and challenges of mRNA technologies in development of dengue virus vaccineXiaoyang LiuDengue virus (DENV) is a mosquito-borne virus with a significant human health concern. With 390 million infections annually and 96 million showing clinical symptoms, severe dengue can lead to life-threatening conditions like dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). The only FDA-approved vaccine, Dengvaxia, has limitations due to antibody-dependent enhancement (ADE), necessitating careful administration. The recent pre-approval of TAK-003 by WHO in 2024 highlights ongoing efforts to improve vaccine options. This review explores recent advancements in dengue vaccine development, emphasizing potential utility of mRNA-based vaccines. By examining current clinical trial data and innovations, we aim to identify promising strategies to address the limitations of existing vaccines and enhance global dengue prevention efforts.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1520968/fulldengueADEmRNA vaccineDENV vaccinetropical diseasevaccine development |
| spellingShingle | Xiaoyang Liu Opportunities and challenges of mRNA technologies in development of dengue virus vaccine Frontiers in Immunology dengue ADE mRNA vaccine DENV vaccine tropical disease vaccine development |
| title | Opportunities and challenges of mRNA technologies in development of dengue virus vaccine |
| title_full | Opportunities and challenges of mRNA technologies in development of dengue virus vaccine |
| title_fullStr | Opportunities and challenges of mRNA technologies in development of dengue virus vaccine |
| title_full_unstemmed | Opportunities and challenges of mRNA technologies in development of dengue virus vaccine |
| title_short | Opportunities and challenges of mRNA technologies in development of dengue virus vaccine |
| title_sort | opportunities and challenges of mrna technologies in development of dengue virus vaccine |
| topic | dengue ADE mRNA vaccine DENV vaccine tropical disease vaccine development |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1520968/full |
| work_keys_str_mv | AT xiaoyangliu opportunitiesandchallengesofmrnatechnologiesindevelopmentofdenguevirusvaccine |