Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs
N-acetyl-d-glucosamine (GlcNAc) is a monosaccharide that polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit of the polymer chitin. GlcNAc is a basic component of hyaluronic acid and keratin sulfate found on the cell surface. The aim of this study was to examine amino acid me...
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MDPI AG
2015-08-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/13/8/5007 |
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| author | Tomohiro Osaki Seiji Kurozumi Kimihiko Sato Taro Terashi Kazuo Azuma Yusuke Murahata Takeshi Tsuka Norihiko Ito Tomohiro Imagawa Saburo Minami Yoshiharu Okamoto |
| author_facet | Tomohiro Osaki Seiji Kurozumi Kimihiko Sato Taro Terashi Kazuo Azuma Yusuke Murahata Takeshi Tsuka Norihiko Ito Tomohiro Imagawa Saburo Minami Yoshiharu Okamoto |
| author_sort | Tomohiro Osaki |
| collection | DOAJ |
| description | N-acetyl-d-glucosamine (GlcNAc) is a monosaccharide that polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit of the polymer chitin. GlcNAc is a basic component of hyaluronic acid and keratin sulfate found on the cell surface. The aim of this study was to examine amino acid metabolism after oral GlcNAc administration in dogs. Results showed that plasma levels of ectoine were significantly higher after oral administration of GlcNAc than prior to administration (p < 0.001). To our knowledge, there have been no reports of increased ectoine concentrations in the plasma. The mechanism by which GlcNAc administration leads to increased ectoine plasma concentration remains unclear; future studies are required to clarify this mechanism. |
| first_indexed | 2024-04-14T01:00:00Z |
| format | Article |
| id | doaj.art-089b6ecfd79243d3bc75002e957adcae |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T01:00:00Z |
| publishDate | 2015-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-089b6ecfd79243d3bc75002e957adcae2022-12-22T02:21:27ZengMDPI AGMarine Drugs1660-33972015-08-011385007501510.3390/md13085007md13085007Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in DogsTomohiro Osaki0Seiji Kurozumi1Kimihiko Sato2Taro Terashi3Kazuo Azuma4Yusuke Murahata5Takeshi Tsuka6Norihiko Ito7Tomohiro Imagawa8Saburo Minami9Yoshiharu Okamoto10Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, JapanKoyo Chemical Co. Ltd., 1-17 Taiyuji-cho, Kita-ku, Osaka 530-0051, JapanKoyo Chemical Co. Ltd., 1-17 Taiyuji-cho, Kita-ku, Osaka 530-0051, JapanKoyo Chemical Co. Ltd., 1-17 Taiyuji-cho, Kita-ku, Osaka 530-0051, JapanDepartment of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, JapanDepartment of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, JapanDepartment of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, JapanDepartment of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, JapanDepartment of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, JapanDepartment of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, JapanDepartment of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, JapanN-acetyl-d-glucosamine (GlcNAc) is a monosaccharide that polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit of the polymer chitin. GlcNAc is a basic component of hyaluronic acid and keratin sulfate found on the cell surface. The aim of this study was to examine amino acid metabolism after oral GlcNAc administration in dogs. Results showed that plasma levels of ectoine were significantly higher after oral administration of GlcNAc than prior to administration (p < 0.001). To our knowledge, there have been no reports of increased ectoine concentrations in the plasma. The mechanism by which GlcNAc administration leads to increased ectoine plasma concentration remains unclear; future studies are required to clarify this mechanism.http://www.mdpi.com/1660-3397/13/8/5007amino acidcartilage regenerationdogN-acetyl-d-glucosamine hydrochlorideTGF-beta |
| spellingShingle | Tomohiro Osaki Seiji Kurozumi Kimihiko Sato Taro Terashi Kazuo Azuma Yusuke Murahata Takeshi Tsuka Norihiko Ito Tomohiro Imagawa Saburo Minami Yoshiharu Okamoto Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs Marine Drugs amino acid cartilage regeneration dog N-acetyl-d-glucosamine hydrochloride TGF-beta |
| title | Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs |
| title_full | Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs |
| title_fullStr | Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs |
| title_full_unstemmed | Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs |
| title_short | Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs |
| title_sort | metabolomic analysis of blood plasma after oral administration of n acetyl d glucosamine in dogs |
| topic | amino acid cartilage regeneration dog N-acetyl-d-glucosamine hydrochloride TGF-beta |
| url | http://www.mdpi.com/1660-3397/13/8/5007 |
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