Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2

Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2

Activation of the extracellular signal-regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersion measurements. These can be described by a global exchange b...

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Bibliographic Details
Main Authors: Jake W Anderson, David Vaisar, David N Jones, Laurel M Pegram, Guy P Vigers, Huifen Chen, John G Moffat, Natalie G Ahn
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-03-01
Series:eLife
Subjects:
MAP kinase
inhibitor
conformation selection
NMR
hydrogen exchange
cancer therapeutics
Online Access:https://elifesciences.org/articles/91507

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