CDK12 inhibition upregulates ATG7 triggering autophagy via AKT/FOXO3 pathway and enhances anti-PD-1 efficacy in colorectal cancer

CDK12 inhibition upregulates ATG7 triggering autophagy via AKT/FOXO3 pathway and enhances anti-PD-1 efficacy in colorectal cancer

As the world’s fourth most deadly cancer, colorectal cancer (CRC) still needed the novel therapeutic drugs and target urgently. Although cyclin-dependent kinase 12 (CDK12) has been shown to be implicated in the malignancy of several types of cancer, its functional role and mechanism in CRC remain la...

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Bibliographic Details
Main Authors: Zimei Wu, Wenxin Zhang, Lu Chen, Tianxiao Wang, Xinhai Wang, Huanying Shi, Liudi Zhang, Mingkang Zhong, Xiaojin Shi, Xiang Mao, Haifei Chen, Qunyi Li
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Pharmacological Research
Subjects:
Cyclin-dependent kinase 12
Autophagy related gene 7
Colorectal cancer
Programmed cell death 1
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824000410

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