Ethnopharmacology, Antimicrobial Potency, and Phytochemistry of African <i>Combretum</i> and <i>Pteleopsis</i> Species (Combretaceae): A Review
Bacterial and fungal resistance to antibiotics is of growing global concern. Plants such as the African <i>Combretum</i> and <i>Pteleopsis</i> species, which are used in traditional medicine for the treatment of infections, could be good sources for antimicrobial extracts, dr...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/2/264 |
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| author | Heidi Silén Enass Y. A. Salih Eunice Ego Mgbeahuruike Pia Fyhrqvist |
| author_facet | Heidi Silén Enass Y. A. Salih Eunice Ego Mgbeahuruike Pia Fyhrqvist |
| author_sort | Heidi Silén |
| collection | DOAJ |
| description | Bacterial and fungal resistance to antibiotics is of growing global concern. Plants such as the African <i>Combretum</i> and <i>Pteleopsis</i> species, which are used in traditional medicine for the treatment of infections, could be good sources for antimicrobial extracts, drug scaffolds, and/or antibiotic adjuvants. In African countries, plant species are often used in combinations as traditional remedies. It is suggested that the plant species enhance the effects of each other in these combination treatments. Thus, the multi-species-containing herbal medications could have a good antimicrobial potency. In addition, plant extracts and compounds are known to potentiate the effects of antibiotics. The objective of this review is to compile the information on the botany, ethnopharmacology, ethnobotany, and appearance in herbal markets of African species of the genera <i>Combretum</i> and <i>Pteleopsis</i>. With this ethnobotanical information as a background, this review summarizes the information on the phytochemistry and antimicrobial potency of the extracts and their active compounds, as well as their combination effects with conventional antibiotics. The databases used for the literature search were Scopus, Elsevier, EBSCOhost, PubMed, Google Scholar, and SciFinder. In summary, a number of <i>Combretum</i> and <i>Pteleopsis</i> species were reported to display significant in vitro antibacterial and antifungal efficacy. Tannins, terpenes, flavonoids, stilbenes, and alkaloids—some of them with good antimicrobial potential—are known from species of the genera <i>Combretum</i> and <i>Pteleopsis</i>. Among the most potent antimicrobial compounds are arjunglucoside I (MIC 1.9 µg/mL) and imberbic acid (MIC 1.56 µg/mL), found in both genera and in some <i>Combretum</i> species, respectively. The in vitro antimicrobial properties of the extracts and compounds of many <i>Combretum</i> and <i>Pteleopsis</i> species support their traditional medicinal uses. |
| first_indexed | 2024-03-11T09:14:37Z |
| format | Article |
| id | doaj.art-089d298f3b3d4d38a61f9b3a68d7fcc6 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T09:14:37Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-089d298f3b3d4d38a61f9b3a68d7fcc62023-11-16T18:42:32ZengMDPI AGAntibiotics2079-63822023-01-0112226410.3390/antibiotics12020264Ethnopharmacology, Antimicrobial Potency, and Phytochemistry of African <i>Combretum</i> and <i>Pteleopsis</i> Species (Combretaceae): A ReviewHeidi Silén0Enass Y. A. Salih1Eunice Ego Mgbeahuruike2Pia Fyhrqvist3Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, 00014 Helsinki, FinlandDivision of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, 00014 Helsinki, FinlandDivision of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, 00014 Helsinki, FinlandDivision of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, 00014 Helsinki, FinlandBacterial and fungal resistance to antibiotics is of growing global concern. Plants such as the African <i>Combretum</i> and <i>Pteleopsis</i> species, which are used in traditional medicine for the treatment of infections, could be good sources for antimicrobial extracts, drug scaffolds, and/or antibiotic adjuvants. In African countries, plant species are often used in combinations as traditional remedies. It is suggested that the plant species enhance the effects of each other in these combination treatments. Thus, the multi-species-containing herbal medications could have a good antimicrobial potency. In addition, plant extracts and compounds are known to potentiate the effects of antibiotics. The objective of this review is to compile the information on the botany, ethnopharmacology, ethnobotany, and appearance in herbal markets of African species of the genera <i>Combretum</i> and <i>Pteleopsis</i>. With this ethnobotanical information as a background, this review summarizes the information on the phytochemistry and antimicrobial potency of the extracts and their active compounds, as well as their combination effects with conventional antibiotics. The databases used for the literature search were Scopus, Elsevier, EBSCOhost, PubMed, Google Scholar, and SciFinder. In summary, a number of <i>Combretum</i> and <i>Pteleopsis</i> species were reported to display significant in vitro antibacterial and antifungal efficacy. Tannins, terpenes, flavonoids, stilbenes, and alkaloids—some of them with good antimicrobial potential—are known from species of the genera <i>Combretum</i> and <i>Pteleopsis</i>. Among the most potent antimicrobial compounds are arjunglucoside I (MIC 1.9 µg/mL) and imberbic acid (MIC 1.56 µg/mL), found in both genera and in some <i>Combretum</i> species, respectively. The in vitro antimicrobial properties of the extracts and compounds of many <i>Combretum</i> and <i>Pteleopsis</i> species support their traditional medicinal uses.https://www.mdpi.com/2079-6382/12/2/264<i>Combretum</i><i>Pteleopsis</i>antibacterialantifungaltraditional medicineantibiotic adjuvants |
| spellingShingle | Heidi Silén Enass Y. A. Salih Eunice Ego Mgbeahuruike Pia Fyhrqvist Ethnopharmacology, Antimicrobial Potency, and Phytochemistry of African <i>Combretum</i> and <i>Pteleopsis</i> Species (Combretaceae): A Review Antibiotics <i>Combretum</i> <i>Pteleopsis</i> antibacterial antifungal traditional medicine antibiotic adjuvants |
| title | Ethnopharmacology, Antimicrobial Potency, and Phytochemistry of African <i>Combretum</i> and <i>Pteleopsis</i> Species (Combretaceae): A Review |
| title_full | Ethnopharmacology, Antimicrobial Potency, and Phytochemistry of African <i>Combretum</i> and <i>Pteleopsis</i> Species (Combretaceae): A Review |
| title_fullStr | Ethnopharmacology, Antimicrobial Potency, and Phytochemistry of African <i>Combretum</i> and <i>Pteleopsis</i> Species (Combretaceae): A Review |
| title_full_unstemmed | Ethnopharmacology, Antimicrobial Potency, and Phytochemistry of African <i>Combretum</i> and <i>Pteleopsis</i> Species (Combretaceae): A Review |
| title_short | Ethnopharmacology, Antimicrobial Potency, and Phytochemistry of African <i>Combretum</i> and <i>Pteleopsis</i> Species (Combretaceae): A Review |
| title_sort | ethnopharmacology antimicrobial potency and phytochemistry of african i combretum i and i pteleopsis i species combretaceae a review |
| topic | <i>Combretum</i> <i>Pteleopsis</i> antibacterial antifungal traditional medicine antibiotic adjuvants |
| url | https://www.mdpi.com/2079-6382/12/2/264 |
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