Characterization of an efficient N-oxygenase from Saccharothrix sp. and its application in the synthesis of azomycin

Characterization of an efficient N-oxygenase from Saccharothrix sp. and its application in the synthesis of azomycin

Abstract Background The nitro group constitutes a significant functional moiety within numerous valuable substances, such as nitroimidazoles, a class of antimicrobial drugs exhibiting broad spectrum activity. Conventional chemical methods for synthesizing nitro compounds suffer from harsh conditions...

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Bibliographic Details
Main Authors: Chuanle Fan, Fang Zhou, Wei Huang, Yi Xue, Chao Xu, Rubing Zhang, Mo Xian, Xinjun Feng
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Biotechnology for Biofuels and Bioproducts
Subjects:
Heme-oxygenase-like diiron oxygenase
Nitro compounds
Site-directed mutation
Whole-cell biocatalysis
Nitroimidazoles
Online Access:https://doi.org/10.1186/s13068-023-02446-5

Internet

https://doi.org/10.1186/s13068-023-02446-5

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