Effect of platelet inhibitors on thrombus burden in patients with acute pulmonary embolism
Venous thromboembolism (VTE) whether provoked or not can be life-threatening due to an acute increase in load on the right ventricle (RV) from obstruction of the pulmonary artery (PA). Treatment for and prevention of VTE involves anti-thrombotic agents; more specifically, medications targeting the a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-01-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2020.1732329 |
| _version_ | 1797684178886590464 |
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| author | Joseph Van Galen Libia Pava Colin Wright Ayman Elbadawi Annelise Hamer Abhishek Chaturvedi Scott J. Cameron |
| author_facet | Joseph Van Galen Libia Pava Colin Wright Ayman Elbadawi Annelise Hamer Abhishek Chaturvedi Scott J. Cameron |
| author_sort | Joseph Van Galen |
| collection | DOAJ |
| description | Venous thromboembolism (VTE) whether provoked or not can be life-threatening due to an acute increase in load on the right ventricle (RV) from obstruction of the pulmonary artery (PA). Treatment for and prevention of VTE involves anti-thrombotic agents; more specifically, medications targeting the anticoagulation cascade. In spite of the widespread acceptance of anticoagulants in the treatment of VTE, there appears to be an ongoing belief that platelet reactivity contributes to thrombus burden in patients with acute pulmonary embolism (PE). This investigation of 398 patients presenting with acute PE evaluated whether anti-platelet medication use, which consisted mostly of aspirin therapy, at the time of presentation, affects PA thrombus burden, RV load, or short-term patient outcomes. We conclude that platelets may have been erroneously incriminated as direct thrombotic mediators in patients with acute PE since aspirin neither decreased PA thrombus burden, nor did aspirin improve short-term mortality following acute PE. |
| first_indexed | 2024-03-12T00:25:49Z |
| format | Article |
| id | doaj.art-089d858af4c643f38d7f3ddc89b7eb1d |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:25:49Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-089d858af4c643f38d7f3ddc89b7eb1d2023-09-15T10:38:07ZengTaylor & Francis GroupPlatelets0953-71041369-16352021-01-0132113814010.1080/09537104.2020.17323291732329Effect of platelet inhibitors on thrombus burden in patients with acute pulmonary embolismJoseph Van Galen0Libia Pava1Colin Wright2Ayman Elbadawi3Annelise Hamer4Abhishek Chaturvedi5Scott J. Cameron6University of VirginiaUniversity of Rochester School of MedicineUniversity of Rochester School of MedicineUniversity of Texas Medical BranchUniversity of Rochester School of MedicineUniversity of Rochester School of MedicineUniversity of Rochester School of MedicineVenous thromboembolism (VTE) whether provoked or not can be life-threatening due to an acute increase in load on the right ventricle (RV) from obstruction of the pulmonary artery (PA). Treatment for and prevention of VTE involves anti-thrombotic agents; more specifically, medications targeting the anticoagulation cascade. In spite of the widespread acceptance of anticoagulants in the treatment of VTE, there appears to be an ongoing belief that platelet reactivity contributes to thrombus burden in patients with acute pulmonary embolism (PE). This investigation of 398 patients presenting with acute PE evaluated whether anti-platelet medication use, which consisted mostly of aspirin therapy, at the time of presentation, affects PA thrombus burden, RV load, or short-term patient outcomes. We conclude that platelets may have been erroneously incriminated as direct thrombotic mediators in patients with acute PE since aspirin neither decreased PA thrombus burden, nor did aspirin improve short-term mortality following acute PE.http://dx.doi.org/10.1080/09537104.2020.1732329aspirinplateletpulmonary embolismthrombus |
| spellingShingle | Joseph Van Galen Libia Pava Colin Wright Ayman Elbadawi Annelise Hamer Abhishek Chaturvedi Scott J. Cameron Effect of platelet inhibitors on thrombus burden in patients with acute pulmonary embolism Platelets aspirin platelet pulmonary embolism thrombus |
| title | Effect of platelet inhibitors on thrombus burden in patients with acute pulmonary embolism |
| title_full | Effect of platelet inhibitors on thrombus burden in patients with acute pulmonary embolism |
| title_fullStr | Effect of platelet inhibitors on thrombus burden in patients with acute pulmonary embolism |
| title_full_unstemmed | Effect of platelet inhibitors on thrombus burden in patients with acute pulmonary embolism |
| title_short | Effect of platelet inhibitors on thrombus burden in patients with acute pulmonary embolism |
| title_sort | effect of platelet inhibitors on thrombus burden in patients with acute pulmonary embolism |
| topic | aspirin platelet pulmonary embolism thrombus |
| url | http://dx.doi.org/10.1080/09537104.2020.1732329 |
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