Monitoring of anesthetic depth and EEG band power using phase lag entropy during propofol anesthesia
Abstract Background Phase lag entropy (PLE) is a novel anesthetic depth indicator that uses four-channel electroencephalography (EEG) to measure the temporal pattern diversity in the phase relationship of frequency signals in the brain. The purpose of the study was to evaluate the anesthetic depth m...
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | BMC Anesthesiology |
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| Online Access: | http://link.springer.com/article/10.1186/s12871-020-00964-5 |
| _version_ | 1818230297646333952 |
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| author | Hye Won Shin Hyun Jung Kim Yoo Kyung Jang Hae Sun You Hyub Huh Yoon Ji Choi Seung Uk Choi Ji Su Hong |
| author_facet | Hye Won Shin Hyun Jung Kim Yoo Kyung Jang Hae Sun You Hyub Huh Yoon Ji Choi Seung Uk Choi Ji Su Hong |
| author_sort | Hye Won Shin |
| collection | DOAJ |
| description | Abstract Background Phase lag entropy (PLE) is a novel anesthetic depth indicator that uses four-channel electroencephalography (EEG) to measure the temporal pattern diversity in the phase relationship of frequency signals in the brain. The purpose of the study was to evaluate the anesthetic depth monitoring using PLE and to evaluate the correlation between PLE and bispectral index (BIS) values during propofol anesthesia. Methods In thirty-five adult patients undergoing elective surgery, anesthesia was induced with propofol using target-controlled infusion (the Schneider model). We recorded the PLE value, raw EEG, BIS value, and hemodynamic data when the target effect-site concentration (Ce) of propofol reached 2, 3, 4, 5, and 6 μg/ml before intubation and 6, 5, 4, 3, 2 μg/ml after intubation and injection of muscle relaxant. We analyzed whether PLE and raw EEG data from the PLE monitor reflected the anesthetic depth as the Ce of propofol changed, and whether PLE values were comparable to BIS values. Results PLE values were inversely correlated to changes in propofol Ce (propofol Ce from 0 to 6.0 μg/ml, r2 = − 0.83; propofol Ce from 6.0 to 2.0 μg/ml, r2 = − 0.46). In the spectral analysis of EEG acquired from the PLE monitor, the persistence spectrogram revealed a wide distribution of power at loss of consciousness (LOC) and recovery of consciousness (ROC), with a narrow distribution during unconsciousness. The power spectrogram showed the typical pattern seen in propofol anesthesia with slow alpha frequency band oscillation. The PLE value demonstrated a strong correlation with the BIS value during the change in propofol Ce from 0 to 6.0 μg/ml (r2 = 0.84). PLE and BIS values were similar at LOC (62.3 vs. 61.8) (P > 0.05), but PLE values were smaller than BIS values at ROC (64.4 vs 75.7) (P < 0.05). Conclusions The PLE value is a useful anesthetic depth indicator, similar to the BIS value, during propofol anesthesia. Spectral analysis of EEG acquired from the PLE monitor demonstrated the typical patterns seen in propofol anesthesia. Trial registration This clinical trial was retrospectively registered at ClinicalTrials.gov at October 2017 ( NCT03299621 ). |
| first_indexed | 2024-12-12T10:32:16Z |
| format | Article |
| id | doaj.art-089dd43e5b5d444bacb786461b3b5099 |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-12-12T10:32:16Z |
| publishDate | 2020-02-01 |
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| series | BMC Anesthesiology |
| spelling | doaj.art-089dd43e5b5d444bacb786461b3b50992022-12-22T00:27:19ZengBMCBMC Anesthesiology1471-22532020-02-0120111010.1186/s12871-020-00964-5Monitoring of anesthetic depth and EEG band power using phase lag entropy during propofol anesthesiaHye Won Shin0Hyun Jung Kim1Yoo Kyung Jang2Hae Sun You3Hyub Huh4Yoon Ji Choi5Seung Uk Choi6Ji Su Hong7Department of Anesthesiology and Pain Medicine, Korea University Anam Hospital, College of Medicine, Korea UniversityDepartment of Anesthesiology and Pain Medicine, Ewha University Magok Hospital, College of Medicine, Ewha UniversityDepartment of Anesthesiology and Pain Medicine, Korea University Anam Hospital, College of Medicine, Korea UniversityDepartment of Anesthesiology and Pain Medicine, Korea University Anam Hospital, College of Medicine, Korea UniversityDepartment of Anesthesiology and Pain Medicine, Korea University Anam Hospital, College of Medicine, Korea UniversityDepartment of Anesthesiology and Pain Medicine, Korea University Ansan Hospital, College of Medicine, Korea UniversityDepartment of Anesthesiology and Pain Medicine, Korea University Anam Hospital, College of Medicine, Korea UniversityDepartment of Anesthesiology and Pain Medicine, Korea University Anam Hospital, College of Medicine, Korea UniversityAbstract Background Phase lag entropy (PLE) is a novel anesthetic depth indicator that uses four-channel electroencephalography (EEG) to measure the temporal pattern diversity in the phase relationship of frequency signals in the brain. The purpose of the study was to evaluate the anesthetic depth monitoring using PLE and to evaluate the correlation between PLE and bispectral index (BIS) values during propofol anesthesia. Methods In thirty-five adult patients undergoing elective surgery, anesthesia was induced with propofol using target-controlled infusion (the Schneider model). We recorded the PLE value, raw EEG, BIS value, and hemodynamic data when the target effect-site concentration (Ce) of propofol reached 2, 3, 4, 5, and 6 μg/ml before intubation and 6, 5, 4, 3, 2 μg/ml after intubation and injection of muscle relaxant. We analyzed whether PLE and raw EEG data from the PLE monitor reflected the anesthetic depth as the Ce of propofol changed, and whether PLE values were comparable to BIS values. Results PLE values were inversely correlated to changes in propofol Ce (propofol Ce from 0 to 6.0 μg/ml, r2 = − 0.83; propofol Ce from 6.0 to 2.0 μg/ml, r2 = − 0.46). In the spectral analysis of EEG acquired from the PLE monitor, the persistence spectrogram revealed a wide distribution of power at loss of consciousness (LOC) and recovery of consciousness (ROC), with a narrow distribution during unconsciousness. The power spectrogram showed the typical pattern seen in propofol anesthesia with slow alpha frequency band oscillation. The PLE value demonstrated a strong correlation with the BIS value during the change in propofol Ce from 0 to 6.0 μg/ml (r2 = 0.84). PLE and BIS values were similar at LOC (62.3 vs. 61.8) (P > 0.05), but PLE values were smaller than BIS values at ROC (64.4 vs 75.7) (P < 0.05). Conclusions The PLE value is a useful anesthetic depth indicator, similar to the BIS value, during propofol anesthesia. Spectral analysis of EEG acquired from the PLE monitor demonstrated the typical patterns seen in propofol anesthesia. Trial registration This clinical trial was retrospectively registered at ClinicalTrials.gov at October 2017 ( NCT03299621 ).http://link.springer.com/article/10.1186/s12871-020-00964-5Anesthetic depth monitoringBispectral indexPhase lag entropyPropofol |
| spellingShingle | Hye Won Shin Hyun Jung Kim Yoo Kyung Jang Hae Sun You Hyub Huh Yoon Ji Choi Seung Uk Choi Ji Su Hong Monitoring of anesthetic depth and EEG band power using phase lag entropy during propofol anesthesia BMC Anesthesiology Anesthetic depth monitoring Bispectral index Phase lag entropy Propofol |
| title | Monitoring of anesthetic depth and EEG band power using phase lag entropy during propofol anesthesia |
| title_full | Monitoring of anesthetic depth and EEG band power using phase lag entropy during propofol anesthesia |
| title_fullStr | Monitoring of anesthetic depth and EEG band power using phase lag entropy during propofol anesthesia |
| title_full_unstemmed | Monitoring of anesthetic depth and EEG band power using phase lag entropy during propofol anesthesia |
| title_short | Monitoring of anesthetic depth and EEG band power using phase lag entropy during propofol anesthesia |
| title_sort | monitoring of anesthetic depth and eeg band power using phase lag entropy during propofol anesthesia |
| topic | Anesthetic depth monitoring Bispectral index Phase lag entropy Propofol |
| url | http://link.springer.com/article/10.1186/s12871-020-00964-5 |
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