Chitosan/Cyclodextrin Nanospheres for Potential Nose-to-Brain Targeting of Idebenone

Chitosan/Cyclodextrin Nanospheres for Potential Nose-to-Brain Targeting of Idebenone

Idebenone (IDE) is a powerful antioxidant that is potentially active towards cerebral diseases, but its low water solubility and fast first pass metabolism reduce its accumulation in the brain, making it ineffective. In this work, we developed cyclodextrin-based chitosan nanospheres (CS NPs) as pote...

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Bibliographic Details
Main Authors: Federica De Gaetano, Nicola d’Avanzo, Antonia Mancuso, Anna De Gaetano, Giuseppe Paladini, Francesco Caridi, Valentina Venuti, Donatella Paolino, Cinzia Anna Ventura
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceuticals
Subjects:
idebenone
chitosan nanospheres
cyclodextrins
in vitro biological studies
FT-IR
Online Access:https://www.mdpi.com/1424-8247/15/10/1206

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