Low estrogen doses normalize testosterone and estradiol levels to the female range in transgender women
OBJECTIVE: The ideal dosage of cross-sex hormones remains unknown. The aim of this study was to evaluate the luteinizing hormone, follicle-stimulating hormone, testosterone, estradiol and prolactin levels after low-dose estrogen therapy with or without cyproterone acetate in transgender women. METH...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2018-05-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322018000100221&lng=en&tlng=en |
| _version_ | 1818470483988840448 |
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| author | Flávia Siqueira Cunha Sorahia Domenice Maria Helena Palma Sircili Berenice Bilharinho de Mendonca Elaine Maria Frade Costa |
| author_facet | Flávia Siqueira Cunha Sorahia Domenice Maria Helena Palma Sircili Berenice Bilharinho de Mendonca Elaine Maria Frade Costa |
| author_sort | Flávia Siqueira Cunha |
| collection | DOAJ |
| description | OBJECTIVE: The ideal dosage of cross-sex hormones remains unknown. The aim of this study was to evaluate the luteinizing hormone, follicle-stimulating hormone, testosterone, estradiol and prolactin levels after low-dose estrogen therapy with or without cyproterone acetate in transgender women. METHODS: The serum hormone and biochemical profiles of 51 transgender women were evaluated before gonadectomy. Hormone therapy consisted of conjugated equine estrogen alone or combined with cyproterone acetate. The daily dose of conjugated equine estrogen was 0.625 mg in 41 subjects and 1.25 mg in 10 subjects, and the daily dose of cyproterone acetate was 50 mg in 42 subjects and 100 mg in one subject. RESULTS: Estrogen-only therapy reduced the testosterone, luteinizing hormone and follicle-stimulating hormone levels from 731.5 to 18 ng/dL, 6.3 to 1.1 U/L and 9.6 to 1.5 U/L, respectively. Estrogen plus cyproterone acetate reduced the testosterone, luteinizing hormone and follicle-stimulating hormone levels from 750 to 21 ng/dL, 6.8 to 0.6 U/L and 10 to 1.0 U/L, respectively. The serum levels of luteinizing hormone, follicle-stimulating hormone, testosterone, estradiol and prolactin in the patients treated with estrogen alone and estrogen plus cyproterone acetate were not significantly different. The group receiving estrogen plus cyproterone acetate had significantly higher levels of gamma-glutamyltransferase than the group receiving estrogen alone. No significant differences in the other biochemical parameters were evident between the patients receiving estrogen alone and estrogen plus cyproterone acetate. CONCLUSION: In our sample of transgender women, lower estrogen doses than those usually prescribed for these subjects were able to adjust the testosterone and estradiol levels to the physiological female range, thus avoiding high estrogen doses and their multiple associated side effects. |
| first_indexed | 2024-04-13T21:38:51Z |
| format | Article |
| id | doaj.art-089f14694a0748baa9b612299a3cf5a3 |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-13T21:38:51Z |
| publishDate | 2018-05-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-089f14694a0748baa9b612299a3cf5a32022-12-22T02:28:51ZengElsevier EspañaClinics1980-53222018-05-0173010.6061/clinics/2018/e86S1807-59322018000100221Low estrogen doses normalize testosterone and estradiol levels to the female range in transgender womenFlávia Siqueira CunhaSorahia DomeniceMaria Helena Palma SirciliBerenice Bilharinho de MendoncaElaine Maria Frade CostaOBJECTIVE: The ideal dosage of cross-sex hormones remains unknown. The aim of this study was to evaluate the luteinizing hormone, follicle-stimulating hormone, testosterone, estradiol and prolactin levels after low-dose estrogen therapy with or without cyproterone acetate in transgender women. METHODS: The serum hormone and biochemical profiles of 51 transgender women were evaluated before gonadectomy. Hormone therapy consisted of conjugated equine estrogen alone or combined with cyproterone acetate. The daily dose of conjugated equine estrogen was 0.625 mg in 41 subjects and 1.25 mg in 10 subjects, and the daily dose of cyproterone acetate was 50 mg in 42 subjects and 100 mg in one subject. RESULTS: Estrogen-only therapy reduced the testosterone, luteinizing hormone and follicle-stimulating hormone levels from 731.5 to 18 ng/dL, 6.3 to 1.1 U/L and 9.6 to 1.5 U/L, respectively. Estrogen plus cyproterone acetate reduced the testosterone, luteinizing hormone and follicle-stimulating hormone levels from 750 to 21 ng/dL, 6.8 to 0.6 U/L and 10 to 1.0 U/L, respectively. The serum levels of luteinizing hormone, follicle-stimulating hormone, testosterone, estradiol and prolactin in the patients treated with estrogen alone and estrogen plus cyproterone acetate were not significantly different. The group receiving estrogen plus cyproterone acetate had significantly higher levels of gamma-glutamyltransferase than the group receiving estrogen alone. No significant differences in the other biochemical parameters were evident between the patients receiving estrogen alone and estrogen plus cyproterone acetate. CONCLUSION: In our sample of transgender women, lower estrogen doses than those usually prescribed for these subjects were able to adjust the testosterone and estradiol levels to the physiological female range, thus avoiding high estrogen doses and their multiple associated side effects.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322018000100221&lng=en&tlng=enTransgender WomanMale-to-Female TranssexualEstrogenCross-Sex Hormone |
| spellingShingle | Flávia Siqueira Cunha Sorahia Domenice Maria Helena Palma Sircili Berenice Bilharinho de Mendonca Elaine Maria Frade Costa Low estrogen doses normalize testosterone and estradiol levels to the female range in transgender women Clinics Transgender Woman Male-to-Female Transsexual Estrogen Cross-Sex Hormone |
| title | Low estrogen doses normalize testosterone and estradiol levels to the female range in transgender women |
| title_full | Low estrogen doses normalize testosterone and estradiol levels to the female range in transgender women |
| title_fullStr | Low estrogen doses normalize testosterone and estradiol levels to the female range in transgender women |
| title_full_unstemmed | Low estrogen doses normalize testosterone and estradiol levels to the female range in transgender women |
| title_short | Low estrogen doses normalize testosterone and estradiol levels to the female range in transgender women |
| title_sort | low estrogen doses normalize testosterone and estradiol levels to the female range in transgender women |
| topic | Transgender Woman Male-to-Female Transsexual Estrogen Cross-Sex Hormone |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322018000100221&lng=en&tlng=en |
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