Anterior and Posterior Left Inferior Frontal Gyrus Contribute to the Implementation of Grammatical Determiners During Language Production
The left inferior frontal gyrus (IFG) is a key region for language comprehension and production. Previous studies point to a preferential involvement of left anterior IFG (aIFG) in lexical and semantic processes, while the posterior IFG (pIFG) has been implicated in supporting syntactic and phonolog...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyg.2020.00685/full |
| _version_ | 1811288957036527616 |
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| author | Byurakn Ishkhanyan Byurakn Ishkhanyan Byurakn Ishkhanyan Violaine Michel Lange Violaine Michel Lange Kasper Boye Jesper Mogensen Anke Karabanov Gesa Hartwigsen Hartwig Roman Siebner Hartwig Roman Siebner Hartwig Roman Siebner |
| author_facet | Byurakn Ishkhanyan Byurakn Ishkhanyan Byurakn Ishkhanyan Violaine Michel Lange Violaine Michel Lange Kasper Boye Jesper Mogensen Anke Karabanov Gesa Hartwigsen Hartwig Roman Siebner Hartwig Roman Siebner Hartwig Roman Siebner |
| author_sort | Byurakn Ishkhanyan |
| collection | DOAJ |
| description | The left inferior frontal gyrus (IFG) is a key region for language comprehension and production. Previous studies point to a preferential involvement of left anterior IFG (aIFG) in lexical and semantic processes, while the posterior IFG (pIFG) has been implicated in supporting syntactic and phonological processes. Here we used focal neuronavigated transcranial magnetic stimulation (TMS) to probe the functional involvement of left IFG in lexical and grammatical processing at the sentence level. We applied 10 Hz TMS effective or sham bursts to left aIFG and pIFG, while healthy volunteers performed an adjective-noun production task contrasting grammatical and lexical determiners. For each trial, we measured the time from the stimulus onset to the moment of articulation (response time) and the time from articulation onset to the end of articulation (duration). Focal TMS of IFG generally delayed response times. The TMS-induced delay in response times was relatively stronger for the grammatical condition compared to the lexical condition, when TMS targeted aIFG. Articulation of the determiner was generally shorter in trials presenting grammatical determiners relative to lexical determiners. The shorter articulation time for grammar determiners was facilitated by effective TMS to pIFG. Together, the effects of TMS on task performance provide novel evidence for a joint involvement of anterior and posterior parts of left IFG in implementing grammatical determiners during language production, suggesting an involvement of aIFG in the initiation and pIFG in the production of grammatically appropriate verbal responses at the sentence level. |
| first_indexed | 2024-04-13T03:45:22Z |
| format | Article |
| id | doaj.art-08a172b5dbc446c8b3d7b3c69e9c20f0 |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-04-13T03:45:22Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-08a172b5dbc446c8b3d7b3c69e9c20f02022-12-22T03:04:01ZengFrontiers Media S.A.Frontiers in Psychology1664-10782020-04-011110.3389/fpsyg.2020.00685500698Anterior and Posterior Left Inferior Frontal Gyrus Contribute to the Implementation of Grammatical Determiners During Language ProductionByurakn Ishkhanyan0Byurakn Ishkhanyan1Byurakn Ishkhanyan2Violaine Michel Lange3Violaine Michel Lange4Kasper Boye5Jesper Mogensen6Anke Karabanov7Gesa Hartwigsen8Hartwig Roman Siebner9Hartwig Roman Siebner10Hartwig Roman Siebner11Department of Nordic Studies and Linguistics, University of Copenhagen, Copenhagen, DenmarkDanish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, DenmarkDepartment of Linguistics, Cognitive Science and Semiotics, Aarhus University, Aarhus, DenmarkDepartment of Nordic Studies and Linguistics, University of Copenhagen, Copenhagen, DenmarkDanish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, DenmarkDepartment of Nordic Studies and Linguistics, University of Copenhagen, Copenhagen, DenmarkThe Unit for Cognitive Neuroscience (UCN), Department of Psychology, University of Copenhagen, Copenhagen, DenmarkDanish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, DenmarkLise Meitner Research Group Cognition and Plasticity, Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Leipzig, GermanyDanish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, DenmarkFaculty of Medical and Health Sciences, Institute for Clinical Medicine, University of Copenhagen, Copenhagen, DenmarkDepartment of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, DenmarkThe left inferior frontal gyrus (IFG) is a key region for language comprehension and production. Previous studies point to a preferential involvement of left anterior IFG (aIFG) in lexical and semantic processes, while the posterior IFG (pIFG) has been implicated in supporting syntactic and phonological processes. Here we used focal neuronavigated transcranial magnetic stimulation (TMS) to probe the functional involvement of left IFG in lexical and grammatical processing at the sentence level. We applied 10 Hz TMS effective or sham bursts to left aIFG and pIFG, while healthy volunteers performed an adjective-noun production task contrasting grammatical and lexical determiners. For each trial, we measured the time from the stimulus onset to the moment of articulation (response time) and the time from articulation onset to the end of articulation (duration). Focal TMS of IFG generally delayed response times. The TMS-induced delay in response times was relatively stronger for the grammatical condition compared to the lexical condition, when TMS targeted aIFG. Articulation of the determiner was generally shorter in trials presenting grammatical determiners relative to lexical determiners. The shorter articulation time for grammar determiners was facilitated by effective TMS to pIFG. Together, the effects of TMS on task performance provide novel evidence for a joint involvement of anterior and posterior parts of left IFG in implementing grammatical determiners during language production, suggesting an involvement of aIFG in the initiation and pIFG in the production of grammatically appropriate verbal responses at the sentence level.https://www.frontiersin.org/article/10.3389/fpsyg.2020.00685/fulllanguage productionBroca’s areagrammarlexiconinterior frontal gyrus |
| spellingShingle | Byurakn Ishkhanyan Byurakn Ishkhanyan Byurakn Ishkhanyan Violaine Michel Lange Violaine Michel Lange Kasper Boye Jesper Mogensen Anke Karabanov Gesa Hartwigsen Hartwig Roman Siebner Hartwig Roman Siebner Hartwig Roman Siebner Anterior and Posterior Left Inferior Frontal Gyrus Contribute to the Implementation of Grammatical Determiners During Language Production Frontiers in Psychology language production Broca’s area grammar lexicon interior frontal gyrus |
| title | Anterior and Posterior Left Inferior Frontal Gyrus Contribute to the Implementation of Grammatical Determiners During Language Production |
| title_full | Anterior and Posterior Left Inferior Frontal Gyrus Contribute to the Implementation of Grammatical Determiners During Language Production |
| title_fullStr | Anterior and Posterior Left Inferior Frontal Gyrus Contribute to the Implementation of Grammatical Determiners During Language Production |
| title_full_unstemmed | Anterior and Posterior Left Inferior Frontal Gyrus Contribute to the Implementation of Grammatical Determiners During Language Production |
| title_short | Anterior and Posterior Left Inferior Frontal Gyrus Contribute to the Implementation of Grammatical Determiners During Language Production |
| title_sort | anterior and posterior left inferior frontal gyrus contribute to the implementation of grammatical determiners during language production |
| topic | language production Broca’s area grammar lexicon interior frontal gyrus |
| url | https://www.frontiersin.org/article/10.3389/fpsyg.2020.00685/full |
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