Salivary Metabolomics for Oral Squamous Cell Carcinoma Diagnosis: A Systematic Review
Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer in which the consumption of tobacco and alcohol is considered to be the main aetiological factor. Salivary metabolome profiling could identify novel biochemical pathways involved in the pathogenesis of various diseases. This...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/4/294 |
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| author | Kacper Nijakowski Dawid Gruszczyński Dariusz Kopała Anna Surdacka |
| author_facet | Kacper Nijakowski Dawid Gruszczyński Dariusz Kopała Anna Surdacka |
| author_sort | Kacper Nijakowski |
| collection | DOAJ |
| description | Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer in which the consumption of tobacco and alcohol is considered to be the main aetiological factor. Salivary metabolome profiling could identify novel biochemical pathways involved in the pathogenesis of various diseases. This systematic review was designed to answer the question “Are salivary metabolites reliable for the diagnosis of oral squamous cell carcinoma?”. Following the inclusion and exclusion criteria, nineteen studies were included (according to PRISMA statement guidelines). In all included studies, the diagnostic material was unstimulated whole saliva, whose metabolome changes were determined by different spectroscopic methods. At the metabolic level, OSCC patients differed significantly not only from healthy subjects but also from patients with oral leukoplakia, lichen planus or other oral potentially malignant disorders. Among the detected salivary metabolites, there were the indicators of the impaired metabolic pathways, such as choline metabolism, amino acid pathways, polyamine metabolism, urea cycle, creatine metabolism, glycolysis or glycerolipid metabolism. In conclusion, saliva contains many potential metabolites, which can be used reliably to early diagnose and monitor staging in patients with OSCC. However, further investigations are necessary to confirm these findings and to identify new salivary metabolic biomarkers. |
| first_indexed | 2024-03-09T04:23:31Z |
| format | Article |
| id | doaj.art-08a227afd5f640bb9334583eaef3eff2 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T04:23:31Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-08a227afd5f640bb9334583eaef3eff22023-12-03T13:42:47ZengMDPI AGMetabolites2218-19892022-03-0112429410.3390/metabo12040294Salivary Metabolomics for Oral Squamous Cell Carcinoma Diagnosis: A Systematic ReviewKacper Nijakowski0Dawid Gruszczyński1Dariusz Kopała2Anna Surdacka3Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, PolandStudent’s Scientific Group, Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, PolandStudent’s Scientific Group, Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, PolandDepartment of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, PolandOral squamous cell carcinoma (OSCC) is the most common type of oral cancer in which the consumption of tobacco and alcohol is considered to be the main aetiological factor. Salivary metabolome profiling could identify novel biochemical pathways involved in the pathogenesis of various diseases. This systematic review was designed to answer the question “Are salivary metabolites reliable for the diagnosis of oral squamous cell carcinoma?”. Following the inclusion and exclusion criteria, nineteen studies were included (according to PRISMA statement guidelines). In all included studies, the diagnostic material was unstimulated whole saliva, whose metabolome changes were determined by different spectroscopic methods. At the metabolic level, OSCC patients differed significantly not only from healthy subjects but also from patients with oral leukoplakia, lichen planus or other oral potentially malignant disorders. Among the detected salivary metabolites, there were the indicators of the impaired metabolic pathways, such as choline metabolism, amino acid pathways, polyamine metabolism, urea cycle, creatine metabolism, glycolysis or glycerolipid metabolism. In conclusion, saliva contains many potential metabolites, which can be used reliably to early diagnose and monitor staging in patients with OSCC. However, further investigations are necessary to confirm these findings and to identify new salivary metabolic biomarkers.https://www.mdpi.com/2218-1989/12/4/294salivametabolomicsmetabolomemetabolitesoral squamous cell carcinomaoral cancer |
| spellingShingle | Kacper Nijakowski Dawid Gruszczyński Dariusz Kopała Anna Surdacka Salivary Metabolomics for Oral Squamous Cell Carcinoma Diagnosis: A Systematic Review Metabolites saliva metabolomics metabolome metabolites oral squamous cell carcinoma oral cancer |
| title | Salivary Metabolomics for Oral Squamous Cell Carcinoma Diagnosis: A Systematic Review |
| title_full | Salivary Metabolomics for Oral Squamous Cell Carcinoma Diagnosis: A Systematic Review |
| title_fullStr | Salivary Metabolomics for Oral Squamous Cell Carcinoma Diagnosis: A Systematic Review |
| title_full_unstemmed | Salivary Metabolomics for Oral Squamous Cell Carcinoma Diagnosis: A Systematic Review |
| title_short | Salivary Metabolomics for Oral Squamous Cell Carcinoma Diagnosis: A Systematic Review |
| title_sort | salivary metabolomics for oral squamous cell carcinoma diagnosis a systematic review |
| topic | saliva metabolomics metabolome metabolites oral squamous cell carcinoma oral cancer |
| url | https://www.mdpi.com/2218-1989/12/4/294 |
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