Finely tuned ionizable lipid nanoparticles for CRISPR/Cas9 ribonucleoprotein delivery and gene editing

Finely tuned ionizable lipid nanoparticles for CRISPR/Cas9 ribonucleoprotein delivery and gene editing

Abstract Nonviral delivery of the CRISPR/Cas9 system provides great benefits for in vivo gene therapy due to the low risk of side effects. However, in vivo gene editing by delivering the Cas9 ribonucleoprotein (RNP) is challenging due to the poor delivery into target tissues and cells. Here, we intr...

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Bibliographic Details
Main Authors: San Hae Im, Mincheol Jang, Ji-Ho Park, Hyun Jung Chung
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Nanobiotechnology
Subjects:
CRISPR/Cas9
Lipid nanoparticles
Ribonucleoprotein
In vivo delivery
Online Access:https://doi.org/10.1186/s12951-024-02427-2

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