Successful Chemotherapy for Diffuse Cystic Lung Metastases during Targeted Therapy with Osimertinib in a Patient with Non-Small-Cell Lung Cancer: A Literature Review and a Rare Case Report
Introduction: Diffuse lung cysts occur owing to several diseases; however, diffuse cystic lung metastases are very rare in the case of lung cancer. We report a rare case of diffuse cystic lung metastases from lung adenocarcinoma and reviewed previously reported cases of cystic lung metastases for lu...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2023-11-01
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| Series: | Case Reports in Oncology |
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| Online Access: | https://beta.karger.com/Article/FullText/534711 |
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| author | Akira Matsukida Takunori Ogawa Tomomi Tanigaki Yusuke Serizawa Masashi Nishimura Shunya Igarashi Yoshiki Kato Akihiko Kawana Yoshifumi Kimizuka |
| author_facet | Akira Matsukida Takunori Ogawa Tomomi Tanigaki Yusuke Serizawa Masashi Nishimura Shunya Igarashi Yoshiki Kato Akihiko Kawana Yoshifumi Kimizuka |
| author_sort | Akira Matsukida |
| collection | DOAJ |
| description | Introduction: Diffuse lung cysts occur owing to several diseases; however, diffuse cystic lung metastases are very rare in the case of lung cancer. We report a rare case of diffuse cystic lung metastases from lung adenocarcinoma and reviewed previously reported cases of cystic lung metastases for lung cancer and determined their characteristics. Case Presentation: A 78-year-old Japanese woman with advanced lung adenocarcinoma was positive for the epidermal growth factor receptor gene mutation exon 21 L858R and had been treated with osimertinib. She presented with multiple bilaterally positioned thin-walled lung cysts and pneumothorax. Lung cysts were diagnosed as cystic lung metastases from lung cancer, and carboplatin, pemetrexed, and pembrolizumab were subsequently administered. All cysts markedly decreased in size, and some disappeared. Conclusion: Effective treatment methods for cystic lung metastases from lung cancer have not been reported. To our knowledge, this is the first case of cystic lung metastases that were successfully treated with chemotherapy. |
| first_indexed | 2024-03-08T23:34:44Z |
| format | Article |
| id | doaj.art-08a71203c51340368ccd5686873d62bf |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-03-08T23:34:44Z |
| publishDate | 2023-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-08a71203c51340368ccd5686873d62bf2023-12-14T07:52:11ZengKarger PublishersCase Reports in Oncology1662-65752023-11-011611409141410.1159/000534711534711Successful Chemotherapy for Diffuse Cystic Lung Metastases during Targeted Therapy with Osimertinib in a Patient with Non-Small-Cell Lung Cancer: A Literature Review and a Rare Case ReportAkira Matsukida0Takunori Ogawa1Tomomi Tanigaki2Yusuke Serizawa3Masashi Nishimura4Shunya Igarashi5Yoshiki Kato6Akihiko Kawana7Yoshifumi Kimizuka8Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, JapanDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, JapanDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, JapanDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, JapanDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, JapanDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, JapanDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, JapanDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, JapanDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, JapanIntroduction: Diffuse lung cysts occur owing to several diseases; however, diffuse cystic lung metastases are very rare in the case of lung cancer. We report a rare case of diffuse cystic lung metastases from lung adenocarcinoma and reviewed previously reported cases of cystic lung metastases for lung cancer and determined their characteristics. Case Presentation: A 78-year-old Japanese woman with advanced lung adenocarcinoma was positive for the epidermal growth factor receptor gene mutation exon 21 L858R and had been treated with osimertinib. She presented with multiple bilaterally positioned thin-walled lung cysts and pneumothorax. Lung cysts were diagnosed as cystic lung metastases from lung cancer, and carboplatin, pemetrexed, and pembrolizumab were subsequently administered. All cysts markedly decreased in size, and some disappeared. Conclusion: Effective treatment methods for cystic lung metastases from lung cancer have not been reported. To our knowledge, this is the first case of cystic lung metastases that were successfully treated with chemotherapy.https://beta.karger.com/Article/FullText/534711diffuse cystic lung metastasisnon-small-cell lung cancerosimertinib |
| spellingShingle | Akira Matsukida Takunori Ogawa Tomomi Tanigaki Yusuke Serizawa Masashi Nishimura Shunya Igarashi Yoshiki Kato Akihiko Kawana Yoshifumi Kimizuka Successful Chemotherapy for Diffuse Cystic Lung Metastases during Targeted Therapy with Osimertinib in a Patient with Non-Small-Cell Lung Cancer: A Literature Review and a Rare Case Report Case Reports in Oncology diffuse cystic lung metastasis non-small-cell lung cancer osimertinib |
| title | Successful Chemotherapy for Diffuse Cystic Lung Metastases during Targeted Therapy with Osimertinib in a Patient with Non-Small-Cell Lung Cancer: A Literature Review and a Rare Case Report |
| title_full | Successful Chemotherapy for Diffuse Cystic Lung Metastases during Targeted Therapy with Osimertinib in a Patient with Non-Small-Cell Lung Cancer: A Literature Review and a Rare Case Report |
| title_fullStr | Successful Chemotherapy for Diffuse Cystic Lung Metastases during Targeted Therapy with Osimertinib in a Patient with Non-Small-Cell Lung Cancer: A Literature Review and a Rare Case Report |
| title_full_unstemmed | Successful Chemotherapy for Diffuse Cystic Lung Metastases during Targeted Therapy with Osimertinib in a Patient with Non-Small-Cell Lung Cancer: A Literature Review and a Rare Case Report |
| title_short | Successful Chemotherapy for Diffuse Cystic Lung Metastases during Targeted Therapy with Osimertinib in a Patient with Non-Small-Cell Lung Cancer: A Literature Review and a Rare Case Report |
| title_sort | successful chemotherapy for diffuse cystic lung metastases during targeted therapy with osimertinib in a patient with non small cell lung cancer a literature review and a rare case report |
| topic | diffuse cystic lung metastasis non-small-cell lung cancer osimertinib |
| url | https://beta.karger.com/Article/FullText/534711 |
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