Natriuretic-like Peptide Lebetin 2 Mediates M2 Macrophage Polarization in LPS-Activated RAW264.7 Cells in an IL-10-Dependent Manner

Natriuretic-like Peptide Lebetin 2 Mediates M2 Macrophage Polarization in LPS-Activated RAW264.7 Cells in an IL-10-Dependent Manner

Snake natriuretic peptide (NP) Lebetin 2 (L2) has been shown to improve cardiac function and reduce fibrosis as well as inflammation by promoting M2-type macrophages in a reperfused myocardial infarction (MI) model. However, the inflammatory mechanism of L2 remains unclear. Therefore, we investigate...

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Bibliographic Details
Main Authors: Dorsaf Bouzazi, Wael Mami, Amor Mosbah, Naziha Marrakchi, Melika Ben Ahmed, Erij Messadi
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Toxins
Subjects:
snake venom-derived natriuretic peptide
lebetin 2
inflammation
cytokines
macrophage polarization
interleukin-10
Online Access:https://www.mdpi.com/2072-6651/15/4/298

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