An IDH-independent mechanism of DNA hypermethylation upon VHL inactivation in cancer

An IDH-independent mechanism of DNA hypermethylation upon VHL inactivation in cancer

Hypermethylation of tumour suppressors and other aberrations of DNA methylation in tumours play a significant role in cancer progression. DNA methylation can be affected by various environmental conditions, including hypoxia. The response to hypoxia is mainly achieved through activation of the trans...

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Bibliographic Details
Main Authors: Artem V. Artemov, Svetlana Zhenilo, Daria Kaplun, Alexey Starshin, Alexey Sokolov, Alexander M. Mazur, Justyna Szpotan, Maciej Gawronski, Martyna Modrzejewska, Daniel Gackowski, Egor B. Prokhortchouk
Format: Article
Language:English
Published: Taylor & Francis Group 2022-08-01
Series:Epigenetics
Subjects:
dna methylation
vhl
hypoxia
hif1a
kidney cancer
Online Access:http://dx.doi.org/10.1080/15592294.2021.1971372

Internet

http://dx.doi.org/10.1080/15592294.2021.1971372

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