Distinct TP53 Mutation Types Exhibit Increased Sensitivity to Ferroptosis Independently of Changes in Iron Regulatory Protein Activity
The tumor suppressor gene <i>TP53</i> is the most commonly mutated gene in human cancer. In addition to loss of tumor suppressor functions, mutations in <i>TP53</i> promote cancer progression by altering cellular iron acquisition and metabolism. A newly identified role for TP...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-09-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/18/6751 |