Intercellular crosstalk between cancer cells and cancer-associated fibroblasts via extracellular vesicles
Abstract Intercellular communication plays an important role in cancer initiation and progression through direct contact and indirect interactions, such as via secretory molecules. Cancer-associated fibroblasts (CAFs) are one of the principal components of such communication with cancer cells, modul...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-022-02784-8 |
| _version_ | 1811303908634525696 |
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| author | Yutaka Naito Yusuke Yoshioka Takahiro Ochiya |
| author_facet | Yutaka Naito Yusuke Yoshioka Takahiro Ochiya |
| author_sort | Yutaka Naito |
| collection | DOAJ |
| description | Abstract Intercellular communication plays an important role in cancer initiation and progression through direct contact and indirect interactions, such as via secretory molecules. Cancer-associated fibroblasts (CAFs) are one of the principal components of such communication with cancer cells, modulating cancer metastasis and tumour mechanics and influencing angiogenesis, the immune system, and therapeutic resistance. Over the past few years, there has been a significant increase in research on extracellular vesicles (EVs) as regulatory agents in intercellular communication. EVs enable the transfer of functional molecules, including proteins, mRNAs and microRNAs (miRNAs), to recipient cells. Cancer cells utilize EVs to dictate the specific characteristics of CAFs within the tumour microenvironment, thereby promoting cancer progression. In response to such “education” by cancer cells, CAFs contribute to cancer progression via EVs. In this review, we summarize experimental data indicating the pivotal roles of EVs in intercellular communication between cancer cells and CAFs. |
| first_indexed | 2024-04-13T07:56:32Z |
| format | Article |
| id | doaj.art-08acc25c8eac45d28af8907afabbc2bf |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-04-13T07:56:32Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-08acc25c8eac45d28af8907afabbc2bf2022-12-22T02:55:23ZengBMCCancer Cell International1475-28672022-11-0122112510.1186/s12935-022-02784-8Intercellular crosstalk between cancer cells and cancer-associated fibroblasts via extracellular vesiclesYutaka Naito0Yusuke Yoshioka1Takahiro Ochiya2Department of Bioregulation, Institute for Advanced Medical Sciences, Nippon Medical SchoolDepartment of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical UniversityDepartment of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical UniversityAbstract Intercellular communication plays an important role in cancer initiation and progression through direct contact and indirect interactions, such as via secretory molecules. Cancer-associated fibroblasts (CAFs) are one of the principal components of such communication with cancer cells, modulating cancer metastasis and tumour mechanics and influencing angiogenesis, the immune system, and therapeutic resistance. Over the past few years, there has been a significant increase in research on extracellular vesicles (EVs) as regulatory agents in intercellular communication. EVs enable the transfer of functional molecules, including proteins, mRNAs and microRNAs (miRNAs), to recipient cells. Cancer cells utilize EVs to dictate the specific characteristics of CAFs within the tumour microenvironment, thereby promoting cancer progression. In response to such “education” by cancer cells, CAFs contribute to cancer progression via EVs. In this review, we summarize experimental data indicating the pivotal roles of EVs in intercellular communication between cancer cells and CAFs.https://doi.org/10.1186/s12935-022-02784-8Cancer-associated fibroblastsExtracellular vesiclesCancer microenvironmentIntercellular communicationNon-coding RNAExosomes |
| spellingShingle | Yutaka Naito Yusuke Yoshioka Takahiro Ochiya Intercellular crosstalk between cancer cells and cancer-associated fibroblasts via extracellular vesicles Cancer Cell International Cancer-associated fibroblasts Extracellular vesicles Cancer microenvironment Intercellular communication Non-coding RNA Exosomes |
| title | Intercellular crosstalk between cancer cells and cancer-associated fibroblasts via extracellular vesicles |
| title_full | Intercellular crosstalk between cancer cells and cancer-associated fibroblasts via extracellular vesicles |
| title_fullStr | Intercellular crosstalk between cancer cells and cancer-associated fibroblasts via extracellular vesicles |
| title_full_unstemmed | Intercellular crosstalk between cancer cells and cancer-associated fibroblasts via extracellular vesicles |
| title_short | Intercellular crosstalk between cancer cells and cancer-associated fibroblasts via extracellular vesicles |
| title_sort | intercellular crosstalk between cancer cells and cancer associated fibroblasts via extracellular vesicles |
| topic | Cancer-associated fibroblasts Extracellular vesicles Cancer microenvironment Intercellular communication Non-coding RNA Exosomes |
| url | https://doi.org/10.1186/s12935-022-02784-8 |
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