Acceptability of on-site rapid HIV/HBV/HCV testing and HBV vaccination among three at-risk populations in distinct community-healthcare outreach centres: the ANRS-SHS 154 CUBE study
Abstract Background HIV, HBV and HCV infections continue to represent major health concerns, especially among key at-risk populations such as men who have sex with men (MSM), people who inject drugs (PWIDs), transgender women (TGW) and sex workers (SW). The objective of the ANRS-CUBE study was to ev...
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| Format: | Article |
| Language: | English |
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BMC
2020-11-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-020-05601-7 |
| _version_ | 1819019452800303104 |
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| author | Ruxandra Calin Véronique Massari Gilles Pialoux Nelly Reydellet Eve Plenel Carole Chauvin Marie Jauffret-Roustide Nesrine Day Georges Kreplak Anaenza Freire Maresca Nicolas Derche Sandra Louis Stanislas Pol Véronique Doré Christine Rouzioux Pierre Chauvin |
| author_facet | Ruxandra Calin Véronique Massari Gilles Pialoux Nelly Reydellet Eve Plenel Carole Chauvin Marie Jauffret-Roustide Nesrine Day Georges Kreplak Anaenza Freire Maresca Nicolas Derche Sandra Louis Stanislas Pol Véronique Doré Christine Rouzioux Pierre Chauvin |
| author_sort | Ruxandra Calin |
| collection | DOAJ |
| description | Abstract Background HIV, HBV and HCV infections continue to represent major health concerns, especially among key at-risk populations such as men who have sex with men (MSM), people who inject drugs (PWIDs), transgender women (TGW) and sex workers (SW). The objective of the ANRS-CUBE study was to evaluate the acceptability of a healthcare, community-based strategy offering a triple rapid HIV-HBV-HCV testing, and HBV vaccination, targeted at three priority groups (MSM, PWIDs and TGW/SWs), in three community centers, in the Paris area. Methods This longitudinal multicentric non-randomized study included all adult volunteers attending one of the three specialized community centers in Paris, between July 2014 and December 2015. HIV, HBV and HCV status and acceptability of HBV vaccination were evaluated. Results A total of 3662, MSM, 80 PWIDs and 72 TGW/SW were recruited in the three centers respectively. Acceptability of rapid tests was 98.5% in MSM and 14.9% in TGW/SWs, but could not be estimated in PWIDs since the number of users attending and the number of proposals were not recorded. User acceptability of HBV vaccination was weak, only 17.9% of the eligible MSM (neither vaccinated, nor infected) agreed to receive the first dose, 12.2% two doses, 5.9% had a complete vaccination. User acceptability of HBV vaccination was greater in PWIDs and TGW/SWs, but decreased for the last doses (66.7 and 53.3% respectively received a first dose, 24.4 and 26.7% a second dose and 6.7 and 0% a third dose). Fifty-three participants (49 MSM and 4 PWIDs) were discovered HIV positive, more than half with a recent infection. All but two HIV positive participants were linked to appropriate care in less than one month. Conclusions Rapid HIV-HCV-HBV screening showed a very high level of acceptability among MSM. Efforts need to be made to improve immediate acceptability for HBV vaccination, especially among MSM, and follow-up doses compliance. Our results show the important role of community centers in reaching targets, often fragile, populations, while also suggesting the need to reinforce on-site human support in terms of testing and vaccination, especially when addressing PWIDs. |
| first_indexed | 2024-12-21T03:35:33Z |
| format | Article |
| id | doaj.art-08adef70f9704e97a8a5f46d9d31ae3c |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-21T03:35:33Z |
| publishDate | 2020-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-08adef70f9704e97a8a5f46d9d31ae3c2022-12-21T19:17:21ZengBMCBMC Infectious Diseases1471-23342020-11-0120111410.1186/s12879-020-05601-7Acceptability of on-site rapid HIV/HBV/HCV testing and HBV vaccination among three at-risk populations in distinct community-healthcare outreach centres: the ANRS-SHS 154 CUBE studyRuxandra Calin0Véronique Massari1Gilles Pialoux2Nelly Reydellet3Eve Plenel4Carole Chauvin5Marie Jauffret-Roustide6Nesrine Day7Georges Kreplak8Anaenza Freire Maresca9Nicolas Derche10Sandra Louis11Stanislas Pol12Véronique Doré13Christine Rouzioux14Pierre Chauvin15Service de Maladies Infectieuses, Hôpital Tenon, Groupe Hospitalier Est, AP-HPInserm, IPLESP, ERES, Institut Pierre-Louis d’épidémiologie et de santé publique, Sorbonne UniversitéService de Maladies Infectieuses, Hôpital Tenon, Groupe Hospitalier Est, AP-HPLe Kiosque, Checkpoint-Paris, Groupe SOSLe Kiosque, Checkpoint-Paris, Groupe SOSLe Kiosque, Checkpoint-Paris, Groupe SOSCermes3, Inserm U988, CNRS UMR8211, EHESS, Université de ParisLaboratoires Centre Biologique Chemin Vert (CBCV)Laboratoires Centre Biologique Chemin Vert (CBCV)ARCAT, Pasaje Latino, Groupe SOSLe Kiosque, Checkpoint-Paris, Groupe SOSCSAPA 110 Les Halles, ARCAT, Groupe SOSAP-HP, Hôpital Cochin, Service d’hépatologieANRS: Agence Nationale de Recherche sur le sida et les hépatites viralesLe Kiosque, Checkpoint-Paris, Groupe SOSInserm, IPLESP, ERES, Institut Pierre-Louis d’épidémiologie et de santé publique, Sorbonne UniversitéAbstract Background HIV, HBV and HCV infections continue to represent major health concerns, especially among key at-risk populations such as men who have sex with men (MSM), people who inject drugs (PWIDs), transgender women (TGW) and sex workers (SW). The objective of the ANRS-CUBE study was to evaluate the acceptability of a healthcare, community-based strategy offering a triple rapid HIV-HBV-HCV testing, and HBV vaccination, targeted at three priority groups (MSM, PWIDs and TGW/SWs), in three community centers, in the Paris area. Methods This longitudinal multicentric non-randomized study included all adult volunteers attending one of the three specialized community centers in Paris, between July 2014 and December 2015. HIV, HBV and HCV status and acceptability of HBV vaccination were evaluated. Results A total of 3662, MSM, 80 PWIDs and 72 TGW/SW were recruited in the three centers respectively. Acceptability of rapid tests was 98.5% in MSM and 14.9% in TGW/SWs, but could not be estimated in PWIDs since the number of users attending and the number of proposals were not recorded. User acceptability of HBV vaccination was weak, only 17.9% of the eligible MSM (neither vaccinated, nor infected) agreed to receive the first dose, 12.2% two doses, 5.9% had a complete vaccination. User acceptability of HBV vaccination was greater in PWIDs and TGW/SWs, but decreased for the last doses (66.7 and 53.3% respectively received a first dose, 24.4 and 26.7% a second dose and 6.7 and 0% a third dose). Fifty-three participants (49 MSM and 4 PWIDs) were discovered HIV positive, more than half with a recent infection. All but two HIV positive participants were linked to appropriate care in less than one month. Conclusions Rapid HIV-HCV-HBV screening showed a very high level of acceptability among MSM. Efforts need to be made to improve immediate acceptability for HBV vaccination, especially among MSM, and follow-up doses compliance. Our results show the important role of community centers in reaching targets, often fragile, populations, while also suggesting the need to reinforce on-site human support in terms of testing and vaccination, especially when addressing PWIDs.http://link.springer.com/article/10.1186/s12879-020-05601-7On-site rapid HIV testingHBV testingHCVHBV vaccinationLinkage-to-careCommunity sites |
| spellingShingle | Ruxandra Calin Véronique Massari Gilles Pialoux Nelly Reydellet Eve Plenel Carole Chauvin Marie Jauffret-Roustide Nesrine Day Georges Kreplak Anaenza Freire Maresca Nicolas Derche Sandra Louis Stanislas Pol Véronique Doré Christine Rouzioux Pierre Chauvin Acceptability of on-site rapid HIV/HBV/HCV testing and HBV vaccination among three at-risk populations in distinct community-healthcare outreach centres: the ANRS-SHS 154 CUBE study BMC Infectious Diseases On-site rapid HIV testing HBV testing HCV HBV vaccination Linkage-to-care Community sites |
| title | Acceptability of on-site rapid HIV/HBV/HCV testing and HBV vaccination among three at-risk populations in distinct community-healthcare outreach centres: the ANRS-SHS 154 CUBE study |
| title_full | Acceptability of on-site rapid HIV/HBV/HCV testing and HBV vaccination among three at-risk populations in distinct community-healthcare outreach centres: the ANRS-SHS 154 CUBE study |
| title_fullStr | Acceptability of on-site rapid HIV/HBV/HCV testing and HBV vaccination among three at-risk populations in distinct community-healthcare outreach centres: the ANRS-SHS 154 CUBE study |
| title_full_unstemmed | Acceptability of on-site rapid HIV/HBV/HCV testing and HBV vaccination among three at-risk populations in distinct community-healthcare outreach centres: the ANRS-SHS 154 CUBE study |
| title_short | Acceptability of on-site rapid HIV/HBV/HCV testing and HBV vaccination among three at-risk populations in distinct community-healthcare outreach centres: the ANRS-SHS 154 CUBE study |
| title_sort | acceptability of on site rapid hiv hbv hcv testing and hbv vaccination among three at risk populations in distinct community healthcare outreach centres the anrs shs 154 cube study |
| topic | On-site rapid HIV testing HBV testing HCV HBV vaccination Linkage-to-care Community sites |
| url | http://link.springer.com/article/10.1186/s12879-020-05601-7 |
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