PD-1 is expressed in cytotoxic granules of NK cells and rapidly mobilized to the cell membrane following recognition of tumor cells

PD-1 is expressed in cytotoxic granules of NK cells and rapidly mobilized to the cell membrane following recognition of tumor cells

The contribution of the T cell-related inhibitory checkpoint PD-1 to the regulation of NK cell activity is still not clear with contradictory results concerning its expression and role in the modulation of NK cell cytotoxicity. We provide novel key findings on the mechanism involved in the regulatio...

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Bibliographic Details
Main Authors: Cecilia Pesini, Sandra Hidalgo, Maykel A. Arias, Llipsy Santiago, Carlota Calvo, Maitane Ocariz-Díez, Dolores Isla, Pilar M. Lanuza, M José Agustín, Eva M Galvez, Ariel Ramírez-Labrada, Julián Pardo
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
PD-1
natural killer cells
adoptive cell therapy
cell cytotoxicity
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2096359

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