Therapeutic potential of bixin on inflammation: a mini review
Chronic inflammation is the underlying mechanism for many diseases. Thus, inflammatory signaling pathways are valuable targets for new treatment modalities. Natural products have gained interest as a potential source of bioactive compounds which provide health benefits in combating inflammatory-rela...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1209248/full |
| _version_ | 1797687093787361280 |
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| author | Saminathan Shadisvaaran Kok-Yong Chin Shahida Mohd-Said Xin-Fang Leong |
| author_facet | Saminathan Shadisvaaran Kok-Yong Chin Shahida Mohd-Said Xin-Fang Leong |
| author_sort | Saminathan Shadisvaaran |
| collection | DOAJ |
| description | Chronic inflammation is the underlying mechanism for many diseases. Thus, inflammatory signaling pathways are valuable targets for new treatment modalities. Natural products have gained interest as a potential source of bioactive compounds which provide health benefits in combating inflammatory-related diseases. Recent reports have linked the medicinal values of Bixa orellana L. with its anti-inflammatory activities. Therefore, this review aims to examine the therapeutic potential of bixin, a major bioactive constituent found in the seeds of B. orellana, on inflammatory-related diseases based on existing in vitro and in vivo evidence. Additionally, the anti-inflammatory mechanism of bixin via signaling pathways is explored and possible toxic effects are addressed. The findings suggest that bixin may ameliorate inflammation via inhibition of toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB), phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) and thioredoxin-interacting protein/NOD-like receptor protein 3 (TXNIP/NLRP3) inflammasome mechanisms. More well-planned clinical studies should be performed to verify its effectiveness and safety profile. |
| first_indexed | 2024-03-12T01:13:21Z |
| format | Article |
| id | doaj.art-08ae6550b789472ebc95117f4566c7b3 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-12T01:13:21Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-08ae6550b789472ebc95117f4566c7b32023-09-13T21:47:07ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-09-011010.3389/fnut.2023.12092481209248Therapeutic potential of bixin on inflammation: a mini reviewSaminathan Shadisvaaran0Kok-Yong Chin1Shahida Mohd-Said2Xin-Fang Leong3Department of Craniofacial Diagnostics and Biosciences, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, MalaysiaDepartment of Restorative Dentistry, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaDepartment of Craniofacial Diagnostics and Biosciences, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaChronic inflammation is the underlying mechanism for many diseases. Thus, inflammatory signaling pathways are valuable targets for new treatment modalities. Natural products have gained interest as a potential source of bioactive compounds which provide health benefits in combating inflammatory-related diseases. Recent reports have linked the medicinal values of Bixa orellana L. with its anti-inflammatory activities. Therefore, this review aims to examine the therapeutic potential of bixin, a major bioactive constituent found in the seeds of B. orellana, on inflammatory-related diseases based on existing in vitro and in vivo evidence. Additionally, the anti-inflammatory mechanism of bixin via signaling pathways is explored and possible toxic effects are addressed. The findings suggest that bixin may ameliorate inflammation via inhibition of toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB), phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) and thioredoxin-interacting protein/NOD-like receptor protein 3 (TXNIP/NLRP3) inflammasome mechanisms. More well-planned clinical studies should be performed to verify its effectiveness and safety profile.https://www.frontiersin.org/articles/10.3389/fnut.2023.1209248/fullannattoBixa orellanabixininflammationsafety |
| spellingShingle | Saminathan Shadisvaaran Kok-Yong Chin Shahida Mohd-Said Xin-Fang Leong Therapeutic potential of bixin on inflammation: a mini review Frontiers in Nutrition annatto Bixa orellana bixin inflammation safety |
| title | Therapeutic potential of bixin on inflammation: a mini review |
| title_full | Therapeutic potential of bixin on inflammation: a mini review |
| title_fullStr | Therapeutic potential of bixin on inflammation: a mini review |
| title_full_unstemmed | Therapeutic potential of bixin on inflammation: a mini review |
| title_short | Therapeutic potential of bixin on inflammation: a mini review |
| title_sort | therapeutic potential of bixin on inflammation a mini review |
| topic | annatto Bixa orellana bixin inflammation safety |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1209248/full |
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