Left atrial volume quantification using coronary calcium score scan: Feasibility, reliability and reproducibility analysis of a standardized approach
Background: Left atrial volume (LAV) is an independent prognosticator of cardiovascular events. We investigated whether LAV could be accurately and reliably measured using coronary calcium score (CAC) scan. Methods: We retrospectively selected consecutive patients that underwent coronary CT angiogra...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-06-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906719300430 |
| _version_ | 1818188757866643456 |
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| author | Andrea Cardona Vincenzo Trovato Haikady N. Nagaraja Subha V. Raman Thura T. Harfi |
| author_facet | Andrea Cardona Vincenzo Trovato Haikady N. Nagaraja Subha V. Raman Thura T. Harfi |
| author_sort | Andrea Cardona |
| collection | DOAJ |
| description | Background: Left atrial volume (LAV) is an independent prognosticator of cardiovascular events. We investigated whether LAV could be accurately and reliably measured using coronary calcium score (CAC) scan. Methods: We retrospectively selected consecutive patients that underwent coronary CT angiography (CCTA) and CAC scans. A standardized approach to calculate LAV on images was implemented. The measurements of the LAV on CAC scans and CCTA were performed one to three weeks apart in a random fashion by two readers blinded to the results of each other. The LAV measurements from CAC scan were compared to those from CCTA using correlation analysis. Inter-observer and intra-observer agreement of LAV measurement using CAC scan was evaluated. Results: Final analysis included one hundred subjects, mean age 52 ± 12 years, 48% male. There was a trend of a marginally larger, albeit not clinically significant, mean LAV calculated using CAC scan compared to that using CCTA: 74.3 vs. 71.0 mL: p < 0.001; for reader 1, and 71.7 vs. 71.2 mL p = 0.06 for reader 2, respectively. LAV using CAC scan and CCTA were highly correlated (R = 0.954, p < 0.001 for reader1 and R = 0.945, p < 0.001 for reader 2). There was high reproducibility within each reader with ICC of 0.951 and 0.989 for readers 1 and 2, respectively (p < 0.001). Finally, there was high inter-observer agreement as indicated by R of 0.97 and ICC of 0.96 (p < 0.001 for both). Conclusions: Quantification of LAV from CAC scan using the proposed standardized approach is feasible, highly reliable and reproducible as compared to CCTA. |
| first_indexed | 2024-12-11T23:32:00Z |
| format | Article |
| id | doaj.art-08af65d3ab634d4d987392e280199b7e |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-12-11T23:32:00Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-08af65d3ab634d4d987392e280199b7e2022-12-22T00:46:01ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672019-06-0123Left atrial volume quantification using coronary calcium score scan: Feasibility, reliability and reproducibility analysis of a standardized approachAndrea Cardona0Vincenzo Trovato1Haikady N. Nagaraja2Subha V. Raman3Thura T. Harfi4The Ohio State University Wexner Medical Center, 473 W 12th Avenue, Suite 200, Columbus, OH, 43210, United States of AmericaThe Ohio State University School of Medicine, 125 Doan Hall, 410 West 10th Avenue, Columbus, OH 43210, United States of AmericaThe Ohio State University College of Public Health, 400 C Cunz Hall, 1841 Neil Avenue, Columbus, OH 43210-1351, United States of AmericaThe Ohio State University Wexner Medical Center, 473 W 12th Avenue, Suite 200, Columbus, OH, 43210, United States of AmericaThe Ohio State University Wexner Medical Center, 473 W 12th Avenue, Suite 200, Columbus, OH, 43210, United States of America; Corresponding author.Background: Left atrial volume (LAV) is an independent prognosticator of cardiovascular events. We investigated whether LAV could be accurately and reliably measured using coronary calcium score (CAC) scan. Methods: We retrospectively selected consecutive patients that underwent coronary CT angiography (CCTA) and CAC scans. A standardized approach to calculate LAV on images was implemented. The measurements of the LAV on CAC scans and CCTA were performed one to three weeks apart in a random fashion by two readers blinded to the results of each other. The LAV measurements from CAC scan were compared to those from CCTA using correlation analysis. Inter-observer and intra-observer agreement of LAV measurement using CAC scan was evaluated. Results: Final analysis included one hundred subjects, mean age 52 ± 12 years, 48% male. There was a trend of a marginally larger, albeit not clinically significant, mean LAV calculated using CAC scan compared to that using CCTA: 74.3 vs. 71.0 mL: p < 0.001; for reader 1, and 71.7 vs. 71.2 mL p = 0.06 for reader 2, respectively. LAV using CAC scan and CCTA were highly correlated (R = 0.954, p < 0.001 for reader1 and R = 0.945, p < 0.001 for reader 2). There was high reproducibility within each reader with ICC of 0.951 and 0.989 for readers 1 and 2, respectively (p < 0.001). Finally, there was high inter-observer agreement as indicated by R of 0.97 and ICC of 0.96 (p < 0.001 for both). Conclusions: Quantification of LAV from CAC scan using the proposed standardized approach is feasible, highly reliable and reproducible as compared to CCTA.http://www.sciencedirect.com/science/article/pii/S2352906719300430 |
| spellingShingle | Andrea Cardona Vincenzo Trovato Haikady N. Nagaraja Subha V. Raman Thura T. Harfi Left atrial volume quantification using coronary calcium score scan: Feasibility, reliability and reproducibility analysis of a standardized approach International Journal of Cardiology: Heart & Vasculature |
| title | Left atrial volume quantification using coronary calcium score scan: Feasibility, reliability and reproducibility analysis of a standardized approach |
| title_full | Left atrial volume quantification using coronary calcium score scan: Feasibility, reliability and reproducibility analysis of a standardized approach |
| title_fullStr | Left atrial volume quantification using coronary calcium score scan: Feasibility, reliability and reproducibility analysis of a standardized approach |
| title_full_unstemmed | Left atrial volume quantification using coronary calcium score scan: Feasibility, reliability and reproducibility analysis of a standardized approach |
| title_short | Left atrial volume quantification using coronary calcium score scan: Feasibility, reliability and reproducibility analysis of a standardized approach |
| title_sort | left atrial volume quantification using coronary calcium score scan feasibility reliability and reproducibility analysis of a standardized approach |
| url | http://www.sciencedirect.com/science/article/pii/S2352906719300430 |
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