Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections

Patients with chronic urinary and urogenital multidrug resistant bacterial infections received phage therapy (PT) using intravesical or intravesical and intravaginal phage administration. A single course of PT did not induce significant serum antibody responses against administered phage. Whilst the...

Full description

Bibliographic Details
Main Authors: Sławomir Letkiewicz, Marzanna Łusiak-Szelachowska, Ryszard Międzybrodzki, Maciej Żaczek, Beata Weber-Dąbrowska, Andrzej Górski
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Antibiotics
Subjects:
Online Access:https://www.mdpi.com/2079-6382/10/6/627
_version_ 1797532770352758784
author Sławomir Letkiewicz
Marzanna Łusiak-Szelachowska
Ryszard Międzybrodzki
Maciej Żaczek
Beata Weber-Dąbrowska
Andrzej Górski
author_facet Sławomir Letkiewicz
Marzanna Łusiak-Szelachowska
Ryszard Międzybrodzki
Maciej Żaczek
Beata Weber-Dąbrowska
Andrzej Górski
author_sort Sławomir Letkiewicz
collection DOAJ
description Patients with chronic urinary and urogenital multidrug resistant bacterial infections received phage therapy (PT) using intravesical or intravesical and intravaginal phage administration. A single course of PT did not induce significant serum antibody responses against administered phage. Whilst the second cycle of PT caused a significant increase in antibody levels, they nevertheless remained quite low. These data combined with good therapy results achieved in some patients suggest that this mode of PT may be an efficient means of therapy for urogenital infections and a reliable model for a clinical trial of PT.
first_indexed 2024-03-10T11:05:01Z
format Article
id doaj.art-08afb847c07f495980acba215da2faa5
institution Directory Open Access Journal
issn 2079-6382
language English
last_indexed 2024-03-10T11:05:01Z
publishDate 2021-05-01
publisher MDPI AG
record_format Article
series Antibiotics
spelling doaj.art-08afb847c07f495980acba215da2faa52023-11-21T21:13:32ZengMDPI AGAntibiotics2079-63822021-05-0110662710.3390/antibiotics10060627Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract InfectionsSławomir Letkiewicz0Marzanna Łusiak-Szelachowska1Ryszard Międzybrodzki2Maciej Żaczek3Beata Weber-Dąbrowska4Andrzej Górski5Phage Therapy Unit, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114 Wrocław, PolandBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114 Wrocław, PolandPhage Therapy Unit, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114 Wrocław, PolandBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114 Wrocław, PolandPhage Therapy Unit, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114 Wrocław, PolandPhage Therapy Unit, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114 Wrocław, PolandPatients with chronic urinary and urogenital multidrug resistant bacterial infections received phage therapy (PT) using intravesical or intravesical and intravaginal phage administration. A single course of PT did not induce significant serum antibody responses against administered phage. Whilst the second cycle of PT caused a significant increase in antibody levels, they nevertheless remained quite low. These data combined with good therapy results achieved in some patients suggest that this mode of PT may be an efficient means of therapy for urogenital infections and a reliable model for a clinical trial of PT.https://www.mdpi.com/2079-6382/10/6/627antibiotic resistanceantiphage antibodyimmune systemphage therapyurogenital tract infections
spellingShingle Sławomir Letkiewicz
Marzanna Łusiak-Szelachowska
Ryszard Międzybrodzki
Maciej Żaczek
Beata Weber-Dąbrowska
Andrzej Górski
Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections
Antibiotics
antibiotic resistance
antiphage antibody
immune system
phage therapy
urogenital tract infections
title Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections
title_full Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections
title_fullStr Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections
title_full_unstemmed Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections
title_short Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections
title_sort low immunogenicity of intravesical phage therapy for urogenitary tract infections
topic antibiotic resistance
antiphage antibody
immune system
phage therapy
urogenital tract infections
url https://www.mdpi.com/2079-6382/10/6/627
work_keys_str_mv AT sławomirletkiewicz lowimmunogenicityofintravesicalphagetherapyforurogenitarytractinfections
AT marzannałusiakszelachowska lowimmunogenicityofintravesicalphagetherapyforurogenitarytractinfections
AT ryszardmiedzybrodzki lowimmunogenicityofintravesicalphagetherapyforurogenitarytractinfections
AT maciejzaczek lowimmunogenicityofintravesicalphagetherapyforurogenitarytractinfections
AT beataweberdabrowska lowimmunogenicityofintravesicalphagetherapyforurogenitarytractinfections
AT andrzejgorski lowimmunogenicityofintravesicalphagetherapyforurogenitarytractinfections