Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections
Patients with chronic urinary and urogenital multidrug resistant bacterial infections received phage therapy (PT) using intravesical or intravesical and intravaginal phage administration. A single course of PT did not induce significant serum antibody responses against administered phage. Whilst the...
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MDPI AG
2021-05-01
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author | Sławomir Letkiewicz Marzanna Łusiak-Szelachowska Ryszard Międzybrodzki Maciej Żaczek Beata Weber-Dąbrowska Andrzej Górski |
author_facet | Sławomir Letkiewicz Marzanna Łusiak-Szelachowska Ryszard Międzybrodzki Maciej Żaczek Beata Weber-Dąbrowska Andrzej Górski |
author_sort | Sławomir Letkiewicz |
collection | DOAJ |
description | Patients with chronic urinary and urogenital multidrug resistant bacterial infections received phage therapy (PT) using intravesical or intravesical and intravaginal phage administration. A single course of PT did not induce significant serum antibody responses against administered phage. Whilst the second cycle of PT caused a significant increase in antibody levels, they nevertheless remained quite low. These data combined with good therapy results achieved in some patients suggest that this mode of PT may be an efficient means of therapy for urogenital infections and a reliable model for a clinical trial of PT. |
first_indexed | 2024-03-10T11:05:01Z |
format | Article |
id | doaj.art-08afb847c07f495980acba215da2faa5 |
institution | Directory Open Access Journal |
issn | 2079-6382 |
language | English |
last_indexed | 2024-03-10T11:05:01Z |
publishDate | 2021-05-01 |
publisher | MDPI AG |
record_format | Article |
series | Antibiotics |
spelling | doaj.art-08afb847c07f495980acba215da2faa52023-11-21T21:13:32ZengMDPI AGAntibiotics2079-63822021-05-0110662710.3390/antibiotics10060627Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract InfectionsSławomir Letkiewicz0Marzanna Łusiak-Szelachowska1Ryszard Międzybrodzki2Maciej Żaczek3Beata Weber-Dąbrowska4Andrzej Górski5Phage Therapy Unit, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114 Wrocław, PolandBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114 Wrocław, PolandPhage Therapy Unit, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114 Wrocław, PolandBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114 Wrocław, PolandPhage Therapy Unit, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114 Wrocław, PolandPhage Therapy Unit, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114 Wrocław, PolandPatients with chronic urinary and urogenital multidrug resistant bacterial infections received phage therapy (PT) using intravesical or intravesical and intravaginal phage administration. A single course of PT did not induce significant serum antibody responses against administered phage. Whilst the second cycle of PT caused a significant increase in antibody levels, they nevertheless remained quite low. These data combined with good therapy results achieved in some patients suggest that this mode of PT may be an efficient means of therapy for urogenital infections and a reliable model for a clinical trial of PT.https://www.mdpi.com/2079-6382/10/6/627antibiotic resistanceantiphage antibodyimmune systemphage therapyurogenital tract infections |
spellingShingle | Sławomir Letkiewicz Marzanna Łusiak-Szelachowska Ryszard Międzybrodzki Maciej Żaczek Beata Weber-Dąbrowska Andrzej Górski Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections Antibiotics antibiotic resistance antiphage antibody immune system phage therapy urogenital tract infections |
title | Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections |
title_full | Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections |
title_fullStr | Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections |
title_full_unstemmed | Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections |
title_short | Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections |
title_sort | low immunogenicity of intravesical phage therapy for urogenitary tract infections |
topic | antibiotic resistance antiphage antibody immune system phage therapy urogenital tract infections |
url | https://www.mdpi.com/2079-6382/10/6/627 |
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