Optimizing NK-92 serial killers: gamma irradiation, CD95/Fas-ligation, and NK or LAK attack limit cytotoxic efficacy

Optimizing NK-92 serial killers: gamma irradiation, CD95/Fas-ligation, and NK or LAK attack limit cytotoxic efficacy

Abstract Background The NK cell line NK-92 and its genetically modified variants are receiving attention as immunotherapies to treat a range of malignancies. However, since NK-92 cells are themselves tumors, they require irradiation prior to transfer and are potentially susceptible to attack by pati...

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Bibliographic Details
Main Authors: Lydia Navarrete-Galvan, Michael Guglielmo, Judith Cruz Amaya, Julie Smith-Gagen, Vincent C. Lombardi, Rebecca Merica, Dorothy Hudig
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Journal of Translational Medicine
Subjects:
NK-92
NK
Radiation
Fas/CD95
Serial killing
Lymphokine activated killer
Online Access:https://doi.org/10.1186/s12967-022-03350-6

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