Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities
Osteoarthritis (OA) is a joint degenerative disease that is an exceedingly common problem associated with aging. Aging is the principal risk factor for OA, but damage-related physiopathology of articular chondrocytes probably drives the mechanisms of joint degeneration by a progressive decline in th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.625497/full |
| _version_ | 1819148731085225984 |
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| author | Thamil Selvee Ramasamy Thamil Selvee Ramasamy Yong Mei Yee Ilyas M. Khan |
| author_facet | Thamil Selvee Ramasamy Thamil Selvee Ramasamy Yong Mei Yee Ilyas M. Khan |
| author_sort | Thamil Selvee Ramasamy |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a joint degenerative disease that is an exceedingly common problem associated with aging. Aging is the principal risk factor for OA, but damage-related physiopathology of articular chondrocytes probably drives the mechanisms of joint degeneration by a progressive decline in the homeostatic and regenerative capacity of cells. Cellular aging is the manifestation of a complex interplay of cellular and molecular pathways underpinned by transcriptional, translational, and epigenetic mechanisms and niche factors, and unraveling this complexity will improve our understanding of underlying molecular changes that affect the ability of the articular cartilage to maintain or regenerate itself. This insight is imperative for developing new cell and drug therapies for OA disease that will target the specific causes of age-related functional decline. This review explores the key age-related changes within articular chondrocytes and discusses the molecular mechanisms that are commonly perturbed as cartilage ages and degenerates. Current efforts and emerging potential therapies in treating OA that are being employed to halt or decelerate the aging processes are also discussed. |
| first_indexed | 2024-12-22T13:50:22Z |
| format | Article |
| id | doaj.art-08b2ab02211a48ed882077af3f018b3c |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-22T13:50:22Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-08b2ab02211a48ed882077af3f018b3c2022-12-21T18:23:40ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-07-01910.3389/fcell.2021.625497625497Chondrocyte Aging: The Molecular Determinants and Therapeutic OpportunitiesThamil Selvee Ramasamy0Thamil Selvee Ramasamy1Yong Mei Yee2Ilyas M. Khan3Stem Cell Biology Laboratory, Department of Molecular Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, MalaysiaCell and Molecular Biology Laboratory, The Dean’s Office, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, MalaysiaStem Cell Biology Laboratory, Department of Molecular Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, MalaysiaCentre of NanoHealth, Swansea University Medical School, Swansea, United KingdomOsteoarthritis (OA) is a joint degenerative disease that is an exceedingly common problem associated with aging. Aging is the principal risk factor for OA, but damage-related physiopathology of articular chondrocytes probably drives the mechanisms of joint degeneration by a progressive decline in the homeostatic and regenerative capacity of cells. Cellular aging is the manifestation of a complex interplay of cellular and molecular pathways underpinned by transcriptional, translational, and epigenetic mechanisms and niche factors, and unraveling this complexity will improve our understanding of underlying molecular changes that affect the ability of the articular cartilage to maintain or regenerate itself. This insight is imperative for developing new cell and drug therapies for OA disease that will target the specific causes of age-related functional decline. This review explores the key age-related changes within articular chondrocytes and discusses the molecular mechanisms that are commonly perturbed as cartilage ages and degenerates. Current efforts and emerging potential therapies in treating OA that are being employed to halt or decelerate the aging processes are also discussed.https://www.frontiersin.org/articles/10.3389/fcell.2021.625497/fullsenescenceosteoarthritischondroprotectiondegenerationregenerative medicine |
| spellingShingle | Thamil Selvee Ramasamy Thamil Selvee Ramasamy Yong Mei Yee Ilyas M. Khan Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities Frontiers in Cell and Developmental Biology senescence osteoarthritis chondroprotection degeneration regenerative medicine |
| title | Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities |
| title_full | Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities |
| title_fullStr | Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities |
| title_full_unstemmed | Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities |
| title_short | Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities |
| title_sort | chondrocyte aging the molecular determinants and therapeutic opportunities |
| topic | senescence osteoarthritis chondroprotection degeneration regenerative medicine |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.625497/full |
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