Alternative temozolomide dosing regimens and novel combinations for the treatment of advanced metastatic melanoma
Over the past 30 years, there has been no significant improvement in treatment outcomes for patients with advanced stage IV metastatic melanoma, and prognosis remains poor. Melanoma is known to be responsive to immunomodulatory agents, to be a highly vascular tumor, and to be fairly resistant to sta...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2011-12-01
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| Series: | Oncology Reviews |
| Subjects: | |
| Online Access: | http://www.oncologyreviews.org/index.php/or/article/view/125 |
| _version_ | 1797963822728740864 |
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| author | Wen-Jen Hwu Ana E. Ayala Ingrid M. Hernandez |
| author_facet | Wen-Jen Hwu Ana E. Ayala Ingrid M. Hernandez |
| author_sort | Wen-Jen Hwu |
| collection | DOAJ |
| description | Over the past 30 years, there has been no significant improvement in treatment outcomes for patients with advanced stage IV metastatic melanoma, and prognosis remains poor. Melanoma is known to be responsive to immunomodulatory agents, to be a highly vascular tumor, and to be fairly resistant to standard cytotoxic chemotherapy. Ongoing research is attempting to find novel combinations that may have therapeutic synergy. Alternative dosedense schedules of temozolomide appear promising and are being actively investigated, based on their potential to overcome chemoresistance to alkylating agents and the proven activity of temozolomide in the brain. Outcomes of studies investigating single-agent temozolomide suggest that it has activity similar to single-agent dacarbazine. Other studies combining temozolomide with either interferon- alfa or thalidomide suggest that the addition of these immunomodulatory agents to temozolomide improves response rates and may improve overall survival. The best results have been achieved with the extended, daily, dosedense temozolomide regimen. Further research is needed to determine the optimal temozolomide regimen and best combination approach |
| first_indexed | 2024-04-11T01:34:19Z |
| format | Article |
| id | doaj.art-08b4ad4fd0b041fda0be0b43c7a7030d |
| institution | Directory Open Access Journal |
| issn | 1970-5557 1970-5565 |
| language | English |
| last_indexed | 2024-04-11T01:34:19Z |
| publishDate | 2011-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Oncology Reviews |
| spelling | doaj.art-08b4ad4fd0b041fda0be0b43c7a7030d2023-01-03T09:00:24ZengFrontiers Media S.A.Oncology Reviews1970-55571970-55652011-12-012310.4081/oncol.2008.183119Alternative temozolomide dosing regimens and novel combinations for the treatment of advanced metastatic melanomaWen-Jen Hwu0Ana E. Ayala1Ingrid M. Hernandez2A.E. Ayala • I.M. Hernandez The University of Texas, MD Anderson Cancer Center, HoustonA.E. Ayala • I.M. Hernandez The University of Texas, MD Anderson Cancer Center, HoustonA.E. Ayala • I.M. Hernandez The University of Texas, MD Anderson Cancer Center, HoustonOver the past 30 years, there has been no significant improvement in treatment outcomes for patients with advanced stage IV metastatic melanoma, and prognosis remains poor. Melanoma is known to be responsive to immunomodulatory agents, to be a highly vascular tumor, and to be fairly resistant to standard cytotoxic chemotherapy. Ongoing research is attempting to find novel combinations that may have therapeutic synergy. Alternative dosedense schedules of temozolomide appear promising and are being actively investigated, based on their potential to overcome chemoresistance to alkylating agents and the proven activity of temozolomide in the brain. Outcomes of studies investigating single-agent temozolomide suggest that it has activity similar to single-agent dacarbazine. Other studies combining temozolomide with either interferon- alfa or thalidomide suggest that the addition of these immunomodulatory agents to temozolomide improves response rates and may improve overall survival. The best results have been achieved with the extended, daily, dosedense temozolomide regimen. Further research is needed to determine the optimal temozolomide regimen and best combination approachhttp://www.oncologyreviews.org/index.php/or/article/view/125Melanoma - Temozolomide - Interferon - Thalidomide - O6-methylguanine DNA methyltransferase |
| spellingShingle | Wen-Jen Hwu Ana E. Ayala Ingrid M. Hernandez Alternative temozolomide dosing regimens and novel combinations for the treatment of advanced metastatic melanoma Oncology Reviews Melanoma - Temozolomide - Interferon - Thalidomide - O6-methylguanine DNA methyltransferase |
| title | Alternative temozolomide dosing regimens and novel combinations for the treatment of advanced metastatic melanoma |
| title_full | Alternative temozolomide dosing regimens and novel combinations for the treatment of advanced metastatic melanoma |
| title_fullStr | Alternative temozolomide dosing regimens and novel combinations for the treatment of advanced metastatic melanoma |
| title_full_unstemmed | Alternative temozolomide dosing regimens and novel combinations for the treatment of advanced metastatic melanoma |
| title_short | Alternative temozolomide dosing regimens and novel combinations for the treatment of advanced metastatic melanoma |
| title_sort | alternative temozolomide dosing regimens and novel combinations for the treatment of advanced metastatic melanoma |
| topic | Melanoma - Temozolomide - Interferon - Thalidomide - O6-methylguanine DNA methyltransferase |
| url | http://www.oncologyreviews.org/index.php/or/article/view/125 |
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