Bcl-2 family proteins: master regulators of cell survival
The most prominent function of proteins of the Bcl-2 family is regulation of the initiation of intrinsic (mitochondrial) pathways of apoptosis. However, recent research has revealed that in addition to regulation of mitochondrial apoptosis, proteins of the Bcl-2 family play important roles in regula...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2016-08-01
|
| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc-2016-0015 |
| _version_ | 1819101928941944832 |
|---|---|
| author | Hatok Jozef Racay Peter |
| author_facet | Hatok Jozef Racay Peter |
| author_sort | Hatok Jozef |
| collection | DOAJ |
| description | The most prominent function of proteins of the Bcl-2 family is regulation of the initiation of intrinsic (mitochondrial) pathways of apoptosis. However, recent research has revealed that in addition to regulation of mitochondrial apoptosis, proteins of the Bcl-2 family play important roles in regulating other cellular pathways with a strong impact on cell survival like autophagy, endoplasmic reticulum (ER) stress response, intracellular calcium dynamics, cell cycle progression, mitochondrial dynamics and energy metabolism. This review summarizes the recent knowledge about functions of Bcl-2 family proteins that are related to cell survival. |
| first_indexed | 2024-12-22T01:26:28Z |
| format | Article |
| id | doaj.art-08b5602b9a6b4ddd9667dd99edd0e864 |
| institution | Directory Open Access Journal |
| issn | 1868-5021 1868-503X |
| language | English |
| last_indexed | 2024-12-22T01:26:28Z |
| publishDate | 2016-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-08b5602b9a6b4ddd9667dd99edd0e8642022-12-21T18:43:35ZengDe GruyterBiomolecular Concepts1868-50211868-503X2016-08-017425927010.1515/bmc-2016-0015Bcl-2 family proteins: master regulators of cell survivalHatok Jozef0Racay Peter1Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin (JFM CU), Biomedical Center Martin and Department of Medical Biochemistry JFM CU, Martin, Slovak RepublicComenius University in Bratislava, Jessenius Faculty of Medicine in Martin (JFM CU), Biomedical Center Martin and Department of Medical Biochemistry JFM CU, Mala Hora 4D, SK-03601 Martin, Slovak RepublicThe most prominent function of proteins of the Bcl-2 family is regulation of the initiation of intrinsic (mitochondrial) pathways of apoptosis. However, recent research has revealed that in addition to regulation of mitochondrial apoptosis, proteins of the Bcl-2 family play important roles in regulating other cellular pathways with a strong impact on cell survival like autophagy, endoplasmic reticulum (ER) stress response, intracellular calcium dynamics, cell cycle progression, mitochondrial dynamics and energy metabolism. This review summarizes the recent knowledge about functions of Bcl-2 family proteins that are related to cell survival.https://doi.org/10.1515/bmc-2016-0015bcl-2 family proteinscalciumcell survivalendoplasmic reticulummitochondria |
| spellingShingle | Hatok Jozef Racay Peter Bcl-2 family proteins: master regulators of cell survival Biomolecular Concepts bcl-2 family proteins calcium cell survival endoplasmic reticulum mitochondria |
| title | Bcl-2 family proteins: master regulators of cell survival |
| title_full | Bcl-2 family proteins: master regulators of cell survival |
| title_fullStr | Bcl-2 family proteins: master regulators of cell survival |
| title_full_unstemmed | Bcl-2 family proteins: master regulators of cell survival |
| title_short | Bcl-2 family proteins: master regulators of cell survival |
| title_sort | bcl 2 family proteins master regulators of cell survival |
| topic | bcl-2 family proteins calcium cell survival endoplasmic reticulum mitochondria |
| url | https://doi.org/10.1515/bmc-2016-0015 |
| work_keys_str_mv | AT hatokjozef bcl2familyproteinsmasterregulatorsofcellsurvival AT racaypeter bcl2familyproteinsmasterregulatorsofcellsurvival |