Interaction between Autonomic Regulation, Adiposity Indexes and Metabolic Profile in Children and Adolescents with Overweight and Obesity
Early obesity predicts initial modifications in cardiac and vascular autonomic regulation. The aim of this study was to assess the possible interaction between non-invasive measures of autonomic cardiovascular control and peripheral endothelium regulation in children with overweight and obesity. We...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | Children |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9067/8/8/686 |
| _version_ | 1797524212477329408 |
|---|---|
| author | Valeria Calcaterra Carlo Palombo Mara Malacarne Massimo Pagani Giovanni Federico Michaela Kozakova Gianvincenzo Zuccotti Daniela Lucini |
| author_facet | Valeria Calcaterra Carlo Palombo Mara Malacarne Massimo Pagani Giovanni Federico Michaela Kozakova Gianvincenzo Zuccotti Daniela Lucini |
| author_sort | Valeria Calcaterra |
| collection | DOAJ |
| description | Early obesity predicts initial modifications in cardiac and vascular autonomic regulation. The aim of this study was to assess the possible interaction between non-invasive measures of autonomic cardiovascular control and peripheral endothelium regulation in children with overweight and obesity. We involved 114 young subjects (77M/37F, 12.7 ± 2.2 years) with normal weight (NW, <i>n</i> = 46) to overweight or obesity (OB, <i>n</i> = 68). Multivariate statistical techniques utilizing a collection of modern indices of autonomic regulation, adiposity indexes and metabolic profile were employed. Resting values show substantial equivalence of data. Conversely, blood pressure variance is greater in NW/OB groups. The correlation matrix between major autonomic and metabolic/hemodynamic variables shows a clustered significant correlation between homogeneous indices. A significant correlation between metabolic indices and endothelial and autonomic control, mostly in its vascular end, was recorded. Particularly, the alpha index is significantly correlated with triglycerides (r = −0.261) and endothelial indices (RHI, r = 0.276). Children with obesity show a link between indices of autonomic and endothelial function, fat distribution and metabolic profile. The optimization of autonomic control, for instance by exercise/nutrition interventions, could potentially prevent/delay the occurrence of structural vascular damage leading to reduced cardiovascular health. |
| first_indexed | 2024-03-10T08:54:11Z |
| format | Article |
| id | doaj.art-08b5f23ff2384e579a89beb94a739ae9 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T08:54:11Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-08b5f23ff2384e579a89beb94a739ae92023-11-22T07:14:26ZengMDPI AGChildren2227-90672021-08-018868610.3390/children8080686Interaction between Autonomic Regulation, Adiposity Indexes and Metabolic Profile in Children and Adolescents with Overweight and ObesityValeria Calcaterra0Carlo Palombo1Mara Malacarne2Massimo Pagani3Giovanni Federico4Michaela Kozakova5Gianvincenzo Zuccotti6Daniela Lucini7Pediatric Department, “V. Buzzi” Children’s Hospital, 20154 Milan, ItalyDepartment of Surgical, Medical, Molecular Pathology and Critical Area Medicine, University of Pisa, 56126 Pisa, ItalyBIOMETRA Department, University of Milan, 20133 Milan, ItalyExercise Medicine Unit, Istituto Auxologico Italiano, 20133 Milan, ItalyPediatric Endocrinology and Diabetes Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyDepartment of Surgical, Medical, Molecular Pathology and Critical Area Medicine, University of Pisa, 56126 Pisa, ItalyPediatric Department, “V. Buzzi” Children’s Hospital, 20154 Milan, ItalyBIOMETRA Department, University of Milan, 20133 Milan, ItalyEarly obesity predicts initial modifications in cardiac and vascular autonomic regulation. The aim of this study was to assess the possible interaction between non-invasive measures of autonomic cardiovascular control and peripheral endothelium regulation in children with overweight and obesity. We involved 114 young subjects (77M/37F, 12.7 ± 2.2 years) with normal weight (NW, <i>n</i> = 46) to overweight or obesity (OB, <i>n</i> = 68). Multivariate statistical techniques utilizing a collection of modern indices of autonomic regulation, adiposity indexes and metabolic profile were employed. Resting values show substantial equivalence of data. Conversely, blood pressure variance is greater in NW/OB groups. The correlation matrix between major autonomic and metabolic/hemodynamic variables shows a clustered significant correlation between homogeneous indices. A significant correlation between metabolic indices and endothelial and autonomic control, mostly in its vascular end, was recorded. Particularly, the alpha index is significantly correlated with triglycerides (r = −0.261) and endothelial indices (RHI, r = 0.276). Children with obesity show a link between indices of autonomic and endothelial function, fat distribution and metabolic profile. The optimization of autonomic control, for instance by exercise/nutrition interventions, could potentially prevent/delay the occurrence of structural vascular damage leading to reduced cardiovascular health.https://www.mdpi.com/2227-9067/8/8/686pediatric obesityautonomic regulationadiposity indexmetabolicchildrenadolescents |
| spellingShingle | Valeria Calcaterra Carlo Palombo Mara Malacarne Massimo Pagani Giovanni Federico Michaela Kozakova Gianvincenzo Zuccotti Daniela Lucini Interaction between Autonomic Regulation, Adiposity Indexes and Metabolic Profile in Children and Adolescents with Overweight and Obesity Children pediatric obesity autonomic regulation adiposity index metabolic children adolescents |
| title | Interaction between Autonomic Regulation, Adiposity Indexes and Metabolic Profile in Children and Adolescents with Overweight and Obesity |
| title_full | Interaction between Autonomic Regulation, Adiposity Indexes and Metabolic Profile in Children and Adolescents with Overweight and Obesity |
| title_fullStr | Interaction between Autonomic Regulation, Adiposity Indexes and Metabolic Profile in Children and Adolescents with Overweight and Obesity |
| title_full_unstemmed | Interaction between Autonomic Regulation, Adiposity Indexes and Metabolic Profile in Children and Adolescents with Overweight and Obesity |
| title_short | Interaction between Autonomic Regulation, Adiposity Indexes and Metabolic Profile in Children and Adolescents with Overweight and Obesity |
| title_sort | interaction between autonomic regulation adiposity indexes and metabolic profile in children and adolescents with overweight and obesity |
| topic | pediatric obesity autonomic regulation adiposity index metabolic children adolescents |
| url | https://www.mdpi.com/2227-9067/8/8/686 |
| work_keys_str_mv | AT valeriacalcaterra interactionbetweenautonomicregulationadiposityindexesandmetabolicprofileinchildrenandadolescentswithoverweightandobesity AT carlopalombo interactionbetweenautonomicregulationadiposityindexesandmetabolicprofileinchildrenandadolescentswithoverweightandobesity AT maramalacarne interactionbetweenautonomicregulationadiposityindexesandmetabolicprofileinchildrenandadolescentswithoverweightandobesity AT massimopagani interactionbetweenautonomicregulationadiposityindexesandmetabolicprofileinchildrenandadolescentswithoverweightandobesity AT giovannifederico interactionbetweenautonomicregulationadiposityindexesandmetabolicprofileinchildrenandadolescentswithoverweightandobesity AT michaelakozakova interactionbetweenautonomicregulationadiposityindexesandmetabolicprofileinchildrenandadolescentswithoverweightandobesity AT gianvincenzozuccotti interactionbetweenautonomicregulationadiposityindexesandmetabolicprofileinchildrenandadolescentswithoverweightandobesity AT danielalucini interactionbetweenautonomicregulationadiposityindexesandmetabolicprofileinchildrenandadolescentswithoverweightandobesity |