Expression of Lineage Transcription Factors Identifies Differences in Transition States of Induced Human Oligodendrocyte Differentiation

Expression of Lineage Transcription Factors Identifies Differences in Transition States of Induced Human Oligodendrocyte Differentiation

Oligodendrocytes (OLs) are critical for myelination and are implicated in several brain disorders. Directed differentiation of human-induced OLs (iOLs) from pluripotent stem cells can be achieved by forced expression of different combinations of the transcription factors SOX10 (S), OLIG2 (O), and NK...

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Bibliographic Details
Main Authors: Florian J. Raabe, Marius Stephan, Jan Benedikt Waldeck, Verena Huber, Damianos Demetriou, Nirmal Kannaiyan, Sabrina Galinski, Laura V. Glaser, Michael C. Wehr, Michael J. Ziller, Andrea Schmitt, Peter Falkai, Moritz J. Rossner
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
directed differentiation
oligodendrocytes
human pluripotent stem cells
hiPSC
scRNAseq
RNA velocity
Online Access:https://www.mdpi.com/2073-4409/11/2/241

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