Asthma-COPD overlap is not a homogeneous disorder: further supporting data
Abstract Asthma-COPD ovelap (ACO) is an umbrella term that encompasses patients with COPD and eosinophilic inflammation (e-COPD) and smoking asthmatics with non-fully reversible airflow obstruction (SA). We compared the clinical characteristics and the inflammatory profile of e-COPD and SA. Patients...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-11-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12931-017-0667-x |
| _version_ | 1828336223010160640 |
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| author | Luis Pérez-de-Llano Borja G. Cosio on behalf of the CHACOS study group |
| author_facet | Luis Pérez-de-Llano Borja G. Cosio on behalf of the CHACOS study group |
| author_sort | Luis Pérez-de-Llano |
| collection | DOAJ |
| description | Abstract Asthma-COPD ovelap (ACO) is an umbrella term that encompasses patients with COPD and eosinophilic inflammation (e-COPD) and smoking asthmatics with non-fully reversible airflow obstruction (SA). We compared the clinical characteristics and the inflammatory profile of e-COPD and SA. Patients classified as e-COPD were older and more often male and showed significantly impaired pulmonary function (likely explained by a heavier smoking habit). On the contrary, SA had more atopic features, more reversibility of airflow obstruction and higher IgE levels. The concentrations of IL-5, IL-13, IL-8, IL-6, TNF-α, IL17 in serum were similar between the 2 groups. However, Th2-related biomarkers (periostin, FeNO and blood eosinophils) shower higher median values in e-COPD patients. Our findings reinforce the notion that ACO is a heterogeneous disorder and, as a consequence, it might be unacceptable to offer the same treatment for two related but different conditions. |
| first_indexed | 2024-04-13T21:57:59Z |
| format | Article |
| id | doaj.art-08b86f6e05b64637a5823e29173e6909 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-04-13T21:57:59Z |
| publishDate | 2017-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-08b86f6e05b64637a5823e29173e69092022-12-22T02:28:12ZengBMCRespiratory Research1465-993X2017-11-011811410.1186/s12931-017-0667-xAsthma-COPD overlap is not a homogeneous disorder: further supporting dataLuis Pérez-de-Llano0Borja G. Cosio1on behalf of the CHACOS study groupDepartment of Respiratory Medicine, Hospital Lucus AugustiDepartment of Respiratory Medicine, Hospital Universitario Son Espases-IdISBaAbstract Asthma-COPD ovelap (ACO) is an umbrella term that encompasses patients with COPD and eosinophilic inflammation (e-COPD) and smoking asthmatics with non-fully reversible airflow obstruction (SA). We compared the clinical characteristics and the inflammatory profile of e-COPD and SA. Patients classified as e-COPD were older and more often male and showed significantly impaired pulmonary function (likely explained by a heavier smoking habit). On the contrary, SA had more atopic features, more reversibility of airflow obstruction and higher IgE levels. The concentrations of IL-5, IL-13, IL-8, IL-6, TNF-α, IL17 in serum were similar between the 2 groups. However, Th2-related biomarkers (periostin, FeNO and blood eosinophils) shower higher median values in e-COPD patients. Our findings reinforce the notion that ACO is a heterogeneous disorder and, as a consequence, it might be unacceptable to offer the same treatment for two related but different conditions.http://link.springer.com/article/10.1186/s12931-017-0667-xEosinophilsPeriostinCOPDAsthmaAsthma-COPD overlapACO |
| spellingShingle | Luis Pérez-de-Llano Borja G. Cosio on behalf of the CHACOS study group Asthma-COPD overlap is not a homogeneous disorder: further supporting data Respiratory Research Eosinophils Periostin COPD Asthma Asthma-COPD overlap ACO |
| title | Asthma-COPD overlap is not a homogeneous disorder: further supporting data |
| title_full | Asthma-COPD overlap is not a homogeneous disorder: further supporting data |
| title_fullStr | Asthma-COPD overlap is not a homogeneous disorder: further supporting data |
| title_full_unstemmed | Asthma-COPD overlap is not a homogeneous disorder: further supporting data |
| title_short | Asthma-COPD overlap is not a homogeneous disorder: further supporting data |
| title_sort | asthma copd overlap is not a homogeneous disorder further supporting data |
| topic | Eosinophils Periostin COPD Asthma Asthma-COPD overlap ACO |
| url | http://link.springer.com/article/10.1186/s12931-017-0667-x |
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