CTCF and transcription influence chromatin structure re-configuration after mitosis

CTCF and transcription influence chromatin structure re-configuration after mitosis

Higher-order chromatin structure is temporarily disrupted during mitosis. Here the authors show that loss of the architectural factor CTCF results in failure to form structural loops and leads to inappropriate cis-regulatory contacts and alterations of compartmental interactions after mitosis. Furth...

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Bibliographic Details
Main Authors: Haoyue Zhang, Jessica Lam, Di Zhang, Yemin Lan, Marit W. Vermunt, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Gerd A. Blobel
Format: Article
Language:English
Published: Nature Portfolio 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25418-5

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