Study protocol: DexaDays-2, hydrocortisone for treatment of dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients: a double-blind placebo controlled randomized intervention study with cross-over design

Study protocol: DexaDays-2, hydrocortisone for treatment of dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients: a double-blind placebo controlled randomized intervention study with cross-over design

Abstract Background Dexamethasone, a highly effective drug in treating pediatric acute lymphoblastic leukemia (ALL), can induce serious neurobehavioral side effects. These side effects are experienced by patients and parents as detrimental with respect to health related quality of life (HRQoL). Base...

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Bibliographic Details
Main Authors: A. M. van Hulst, E. J. Verwaaijen, M. F. Fiocco, S. M. F. Pluijm, M. A. Grootenhuis, R. Pieters, E. L. T. van den Akker, M. M. van den Heuvel-Eibrink
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Pediatrics
Subjects:
Acute Lymphoblastic Leukemia (ALL)
Dexamethasone
Hydrocortisone
Neurobehavioral Side Effects
Behavior
Mood
Online Access:https://doi.org/10.1186/s12887-021-02896-6

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