Novel Photo- and Thermo-Responsive Nanocomposite Hydrogels Based on Functionalized rGO and Modified SIS/Chitosan Polymers for Localized Treatment of Malignant Cutaneous Melanoma
Melanoma is an aggressive type of skin cancer that accounts for over 75% of skin cancer deaths despite comprising less than 5% of all skin cancers. Despite promising improvements in surgical approaches for melanoma resection, the survival of undetectable microtumor residues has remained a concern. A...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.947616/full |
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| author | Daniela N. Céspedes-Valenzuela Santiago Sánchez-Rentería Javier Cifuentes Saul C. Gómez Julian A. Serna Laura Rueda-Gensini Carlos Ostos Carolina Muñoz-Camargo Juan C. Cruz |
| author_facet | Daniela N. Céspedes-Valenzuela Santiago Sánchez-Rentería Javier Cifuentes Saul C. Gómez Julian A. Serna Laura Rueda-Gensini Carlos Ostos Carolina Muñoz-Camargo Juan C. Cruz |
| author_sort | Daniela N. Céspedes-Valenzuela |
| collection | DOAJ |
| description | Melanoma is an aggressive type of skin cancer that accounts for over 75% of skin cancer deaths despite comprising less than 5% of all skin cancers. Despite promising improvements in surgical approaches for melanoma resection, the survival of undetectable microtumor residues has remained a concern. As a result, hyperthermia- and drug-based therapies have grown as attractive techniques to target and treat cancer. In this work, we aim to develop a stimuli-responsive hydrogel based on chitosan methacrylate (ChiMA), porcine small intestine submucosa methacrylate (SISMA), and doxorubicin-functionalized reduced graphene oxide (rGO-DOX) that eliminates microtumor residues from surgically resected melanoma through the coupled effect of NIR light-induced photothermal therapy and heat-induced doxorubicin release. Furthermore, we developed an in silico model to optimize heat and mass transport and evaluate the proposed chemo/photothermal therapy in vitro over melanoma cell cultures. |
| first_indexed | 2024-04-13T11:46:49Z |
| format | Article |
| id | doaj.art-08bb4d3f974a4d568c3415889e85e406 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-13T11:46:49Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-08bb4d3f974a4d568c3415889e85e4062022-12-22T02:48:10ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-07-011010.3389/fbioe.2022.947616947616Novel Photo- and Thermo-Responsive Nanocomposite Hydrogels Based on Functionalized rGO and Modified SIS/Chitosan Polymers for Localized Treatment of Malignant Cutaneous MelanomaDaniela N. Céspedes-Valenzuela0Santiago Sánchez-Rentería1Javier Cifuentes2Saul C. Gómez3Julian A. Serna4Laura Rueda-Gensini5Carlos Ostos6Carolina Muñoz-Camargo7Juan C. Cruz8Grupo de Investigación en Nanobiomateriales, Ingeniería Celular y Bioimpresión (GINIB), Department of Biomedical Engineering, Universidad de Los Andes, Bogotá, ColombiaGrupo de Investigación en Nanobiomateriales, Ingeniería Celular y Bioimpresión (GINIB), Department of Biomedical Engineering, Universidad de Los Andes, Bogotá, ColombiaGrupo de Investigación en Nanobiomateriales, Ingeniería Celular y Bioimpresión (GINIB), Department of Biomedical Engineering, Universidad de Los Andes, Bogotá, ColombiaGrupo de Investigación en Nanobiomateriales, Ingeniería Celular y Bioimpresión (GINIB), Department of Biomedical Engineering, Universidad de Los Andes, Bogotá, ColombiaGrupo de Investigación en Nanobiomateriales, Ingeniería Celular y Bioimpresión (GINIB), Department of Biomedical Engineering, Universidad de Los Andes, Bogotá, ColombiaGrupo de Investigación en Nanobiomateriales, Ingeniería Celular y Bioimpresión (GINIB), Department of Biomedical Engineering, Universidad de Los Andes, Bogotá, ColombiaGrupo CATALAD, Instituto de Química, Universidad de Antioquia, Medellín, ColombiaGrupo de Investigación en Nanobiomateriales, Ingeniería Celular y Bioimpresión (GINIB), Department of Biomedical Engineering, Universidad de Los Andes, Bogotá, ColombiaGrupo de Investigación en Nanobiomateriales, Ingeniería Celular y Bioimpresión (GINIB), Department of Biomedical Engineering, Universidad de Los Andes, Bogotá, ColombiaMelanoma is an aggressive type of skin cancer that accounts for over 75% of skin cancer deaths despite comprising less than 5% of all skin cancers. Despite promising improvements in surgical approaches for melanoma resection, the survival of undetectable microtumor residues has remained a concern. As a result, hyperthermia- and drug-based therapies have grown as attractive techniques to target and treat cancer. In this work, we aim to develop a stimuli-responsive hydrogel based on chitosan methacrylate (ChiMA), porcine small intestine submucosa methacrylate (SISMA), and doxorubicin-functionalized reduced graphene oxide (rGO-DOX) that eliminates microtumor residues from surgically resected melanoma through the coupled effect of NIR light-induced photothermal therapy and heat-induced doxorubicin release. Furthermore, we developed an in silico model to optimize heat and mass transport and evaluate the proposed chemo/photothermal therapy in vitro over melanoma cell cultures.https://www.frontiersin.org/articles/10.3389/fbioe.2022.947616/fullmelanomaphotothermal therapymethacrylationreduced graphene oxideCOMSOL multiphysics |
| spellingShingle | Daniela N. Céspedes-Valenzuela Santiago Sánchez-Rentería Javier Cifuentes Saul C. Gómez Julian A. Serna Laura Rueda-Gensini Carlos Ostos Carolina Muñoz-Camargo Juan C. Cruz Novel Photo- and Thermo-Responsive Nanocomposite Hydrogels Based on Functionalized rGO and Modified SIS/Chitosan Polymers for Localized Treatment of Malignant Cutaneous Melanoma Frontiers in Bioengineering and Biotechnology melanoma photothermal therapy methacrylation reduced graphene oxide COMSOL multiphysics |
| title | Novel Photo- and Thermo-Responsive Nanocomposite Hydrogels Based on Functionalized rGO and Modified SIS/Chitosan Polymers for Localized Treatment of Malignant Cutaneous Melanoma |
| title_full | Novel Photo- and Thermo-Responsive Nanocomposite Hydrogels Based on Functionalized rGO and Modified SIS/Chitosan Polymers for Localized Treatment of Malignant Cutaneous Melanoma |
| title_fullStr | Novel Photo- and Thermo-Responsive Nanocomposite Hydrogels Based on Functionalized rGO and Modified SIS/Chitosan Polymers for Localized Treatment of Malignant Cutaneous Melanoma |
| title_full_unstemmed | Novel Photo- and Thermo-Responsive Nanocomposite Hydrogels Based on Functionalized rGO and Modified SIS/Chitosan Polymers for Localized Treatment of Malignant Cutaneous Melanoma |
| title_short | Novel Photo- and Thermo-Responsive Nanocomposite Hydrogels Based on Functionalized rGO and Modified SIS/Chitosan Polymers for Localized Treatment of Malignant Cutaneous Melanoma |
| title_sort | novel photo and thermo responsive nanocomposite hydrogels based on functionalized rgo and modified sis chitosan polymers for localized treatment of malignant cutaneous melanoma |
| topic | melanoma photothermal therapy methacrylation reduced graphene oxide COMSOL multiphysics |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.947616/full |
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