ACE2 mouse models: a toolbox for cardiovascular and pulmonary research
Angiotensin-converting enzyme 2 (ACE2) is a cell surface enzyme previously shown to mediate SARS-CoV, and now SARS-CoV-2, entry into host cells. Here the authors review existing mouse ACE2 models expressing humanized, transgenic, knockout, knockin, conditional and reporter alleles to provide a toolb...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18880-0 |
| _version_ | 1819289801736585216 |
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| author | Hongpeng Jia Xinping Yue Eric Lazartigues |
| author_facet | Hongpeng Jia Xinping Yue Eric Lazartigues |
| author_sort | Hongpeng Jia |
| collection | DOAJ |
| description | Angiotensin-converting enzyme 2 (ACE2) is a cell surface enzyme previously shown to mediate SARS-CoV, and now SARS-CoV-2, entry into host cells. Here the authors review existing mouse ACE2 models expressing humanized, transgenic, knockout, knockin, conditional and reporter alleles to provide a toolbox for COVID-19 research. |
| first_indexed | 2024-12-24T03:12:37Z |
| format | Article |
| id | doaj.art-08bc4a982ef54372a2046b9be84190d6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-24T03:12:37Z |
| publishDate | 2020-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-08bc4a982ef54372a2046b9be84190d62022-12-21T17:17:43ZengNature PortfolioNature Communications2041-17232020-10-0111111110.1038/s41467-020-18880-0ACE2 mouse models: a toolbox for cardiovascular and pulmonary researchHongpeng Jia0Xinping Yue1Eric Lazartigues2Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of MedicineDepartment of Physiology, Louisiana State University Health Sciences CenterDepartment of Pharmacology & Experimental Therapeutics, Louisiana State University Health Sciences CenterAngiotensin-converting enzyme 2 (ACE2) is a cell surface enzyme previously shown to mediate SARS-CoV, and now SARS-CoV-2, entry into host cells. Here the authors review existing mouse ACE2 models expressing humanized, transgenic, knockout, knockin, conditional and reporter alleles to provide a toolbox for COVID-19 research.https://doi.org/10.1038/s41467-020-18880-0 |
| spellingShingle | Hongpeng Jia Xinping Yue Eric Lazartigues ACE2 mouse models: a toolbox for cardiovascular and pulmonary research Nature Communications |
| title | ACE2 mouse models: a toolbox for cardiovascular and pulmonary research |
| title_full | ACE2 mouse models: a toolbox for cardiovascular and pulmonary research |
| title_fullStr | ACE2 mouse models: a toolbox for cardiovascular and pulmonary research |
| title_full_unstemmed | ACE2 mouse models: a toolbox for cardiovascular and pulmonary research |
| title_short | ACE2 mouse models: a toolbox for cardiovascular and pulmonary research |
| title_sort | ace2 mouse models a toolbox for cardiovascular and pulmonary research |
| url | https://doi.org/10.1038/s41467-020-18880-0 |
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