Registered report: The CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012. This Registered report describes the proposed replication plan of key exp...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2015-01-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/04586 |
| _version_ | 1828203287940169728 |
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| author | Denise Chroscinski Nimet Maherali Erin Griner Reproducibility Project: Cancer Biology |
| author_facet | Denise Chroscinski Nimet Maherali Erin Griner Reproducibility Project: Cancer Biology |
| author_sort | Denise Chroscinski |
| collection | DOAJ |
| description | The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012. This Registered report describes the proposed replication plan of key experiments from ‘The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors’ by Willingham et al., 2012, published in PNAS in 2012. The key experiments being replicated are those reported in Figure 6A–C and Table S4. In these experiments, Willingham et al., 2012 test the safety and efficacy of anti-CD47 antibody treatment in immune competent mice utilizing a syngeneic model of mammary tumor growth in FVB mice. The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange, and the results of the replications will be published in eLife. |
| first_indexed | 2024-04-12T12:03:07Z |
| format | Article |
| id | doaj.art-08be8ee43718424897a97cf05b3c193b |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T12:03:07Z |
| publishDate | 2015-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-08be8ee43718424897a97cf05b3c193b2022-12-22T03:33:47ZengeLife Sciences Publications LtdeLife2050-084X2015-01-01410.7554/eLife.04586Registered report: The CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumorsDenise Chroscinski0Nimet Maherali1Erin Griner2Reproducibility Project: Cancer BiologyNoble Life Sciences, Gaithersburg, United StatesHarvard Stem Cell Institute, Cambridge, United StatesUniversity of Virginia, Charlottesville, United StatesThe Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012. This Registered report describes the proposed replication plan of key experiments from ‘The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors’ by Willingham et al., 2012, published in PNAS in 2012. The key experiments being replicated are those reported in Figure 6A–C and Table S4. In these experiments, Willingham et al., 2012 test the safety and efficacy of anti-CD47 antibody treatment in immune competent mice utilizing a syngeneic model of mammary tumor growth in FVB mice. The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange, and the results of the replications will be published in eLife.https://elifesciences.org/articles/04586Reproducibility Project: Cancer BiologymethodologyCD47targeted therapy |
| spellingShingle | Denise Chroscinski Nimet Maherali Erin Griner Reproducibility Project: Cancer Biology Registered report: The CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors eLife Reproducibility Project: Cancer Biology methodology CD47 targeted therapy |
| title | Registered report: The CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors |
| title_full | Registered report: The CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors |
| title_fullStr | Registered report: The CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors |
| title_full_unstemmed | Registered report: The CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors |
| title_short | Registered report: The CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors |
| title_sort | registered report the cd47 signal regulated protein alpha sirpa interaction is a therapeutic target for human solid tumors |
| topic | Reproducibility Project: Cancer Biology methodology CD47 targeted therapy |
| url | https://elifesciences.org/articles/04586 |
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