PRMT5 activates AKT via methylation to promote tumor metastasis
‘Protein arginine methyltransferase 5 (PRMT5) is known to regulate the expression of genes involved in metastasis. Here, the authors show that PRMT5 methylates Akt and methylation is required for phosphorylation and activation of Akt; ultimately leading to the increase in expression of pro-metastati...
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Bibliographic Details
| Main Authors: |
Lei Huang,
Xiao-Ou Zhang,
Esteban J. Rozen,
Xiaomei Sun,
Benjamin Sallis,
Odette Verdejo-Torres,
Kim Wigglesworth,
Daniel Moon,
Tingting Huang,
John P. Cavaretta,
Gang Wang,
Lei Zhang,
Jason M. Shohet,
Mary M. Lee,
Qiong Wu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-31645-1
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