PRMT5 activates AKT via methylation to promote tumor metastasis
‘Protein arginine methyltransferase 5 (PRMT5) is known to regulate the expression of genes involved in metastasis. Here, the authors show that PRMT5 methylates Akt and methylation is required for phosphorylation and activation of Akt; ultimately leading to the increase in expression of pro-metastati...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31645-1 |
| _version_ | 1828426817178959872 |
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| author | Lei Huang Xiao-Ou Zhang Esteban J. Rozen Xiaomei Sun Benjamin Sallis Odette Verdejo-Torres Kim Wigglesworth Daniel Moon Tingting Huang John P. Cavaretta Gang Wang Lei Zhang Jason M. Shohet Mary M. Lee Qiong Wu |
| author_facet | Lei Huang Xiao-Ou Zhang Esteban J. Rozen Xiaomei Sun Benjamin Sallis Odette Verdejo-Torres Kim Wigglesworth Daniel Moon Tingting Huang John P. Cavaretta Gang Wang Lei Zhang Jason M. Shohet Mary M. Lee Qiong Wu |
| author_sort | Lei Huang |
| collection | DOAJ |
| description | ‘Protein arginine methyltransferase 5 (PRMT5) is known to regulate the expression of genes involved in metastasis. Here, the authors show that PRMT5 methylates Akt and methylation is required for phosphorylation and activation of Akt; ultimately leading to the increase in expression of pro-metastatic transcription factors. |
| first_indexed | 2024-12-10T16:51:55Z |
| format | Article |
| id | doaj.art-08beede925d14353979613ff4f723b89 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-10T16:51:55Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-08beede925d14353979613ff4f723b892022-12-22T01:40:51ZengNature PortfolioNature Communications2041-17232022-07-0113111610.1038/s41467-022-31645-1PRMT5 activates AKT via methylation to promote tumor metastasisLei Huang0Xiao-Ou Zhang1Esteban J. Rozen2Xiaomei Sun3Benjamin Sallis4Odette Verdejo-Torres5Kim Wigglesworth6Daniel Moon7Tingting Huang8John P. Cavaretta9Gang Wang10Lei Zhang11Jason M. Shohet12Mary M. Lee13Qiong Wu14Department of Pediatrics, University of Massachusetts Chan Medical SchoolProgram in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical SchoolDepartment of Pediatrics, University of Massachusetts Chan Medical SchoolDepartment of Pediatrics, University of Massachusetts Chan Medical SchoolDepartment of Microbiology and Physiological System, University of Massachusetts Chan Medical SchoolDepartment of Pediatrics, University of Massachusetts Chan Medical SchoolDepartment of Pediatrics, University of Massachusetts Chan Medical SchoolDepartment of Biology, Tufts UniversityDepartment of Pediatrics, University of Massachusetts Chan Medical SchoolDepartment of Pediatrics, University of Massachusetts Chan Medical SchoolDepartment of Pediatrics, University of Massachusetts Chan Medical SchoolDepartment of Pediatrics, University of Massachusetts Chan Medical SchoolDepartment of Pediatrics, University of Massachusetts Chan Medical SchoolSidney Kimmel Medical College, Thomas Jefferson UniversityDepartment of Pediatrics, University of Massachusetts Chan Medical School‘Protein arginine methyltransferase 5 (PRMT5) is known to regulate the expression of genes involved in metastasis. Here, the authors show that PRMT5 methylates Akt and methylation is required for phosphorylation and activation of Akt; ultimately leading to the increase in expression of pro-metastatic transcription factors.https://doi.org/10.1038/s41467-022-31645-1 |
| spellingShingle | Lei Huang Xiao-Ou Zhang Esteban J. Rozen Xiaomei Sun Benjamin Sallis Odette Verdejo-Torres Kim Wigglesworth Daniel Moon Tingting Huang John P. Cavaretta Gang Wang Lei Zhang Jason M. Shohet Mary M. Lee Qiong Wu PRMT5 activates AKT via methylation to promote tumor metastasis Nature Communications |
| title | PRMT5 activates AKT via methylation to promote tumor metastasis |
| title_full | PRMT5 activates AKT via methylation to promote tumor metastasis |
| title_fullStr | PRMT5 activates AKT via methylation to promote tumor metastasis |
| title_full_unstemmed | PRMT5 activates AKT via methylation to promote tumor metastasis |
| title_short | PRMT5 activates AKT via methylation to promote tumor metastasis |
| title_sort | prmt5 activates akt via methylation to promote tumor metastasis |
| url | https://doi.org/10.1038/s41467-022-31645-1 |
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