Pearl Powder Hybrid Bioactive Scaffolds from Microfluidic 3D Printing for Bone Regeneration
Abstract The development of bioactive scaffolds by mimicking bone tissue extracellular matrix is promising for bone regeneration. Herein, inspired by the bone tissue composition, a novel pearl powder (PP) hybrid fish gelatin methacrylate (GelMa) hydrogel scaffold loaded with vascular endothelial gro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-12-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202304190 |
| _version_ | 1797401795883958272 |
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| author | Lei Yang Lu Fan Xiang Lin Yunru Yu Yuanjin Zhao |
| author_facet | Lei Yang Lu Fan Xiang Lin Yunru Yu Yuanjin Zhao |
| author_sort | Lei Yang |
| collection | DOAJ |
| description | Abstract The development of bioactive scaffolds by mimicking bone tissue extracellular matrix is promising for bone regeneration. Herein, inspired by the bone tissue composition, a novel pearl powder (PP) hybrid fish gelatin methacrylate (GelMa) hydrogel scaffold loaded with vascular endothelial growth factor (VEGF) for bone regeneration is presented. With the help of microfluidic‐assisted 3D printing technology, the composition and structure of the hybrid scaffold can be accurately controlled to meet clinical requirements. The combination of fish skin GelMa and PP also endowed the hybrid scaffold with good biocompatibility, cell adhesion, and osteogenic differentiation ability. Moreover, the controlled release of VEGF enables the scaffold to promote angiogenesis. Thus, the bone regeneration in the proposed scaffolds could be accelerated under the synergic effect of osteogenesis and angiogenesis, which has been proved in the rat skull defect model. These features indicate that the PP hybrid scaffolds will be an ideal candidate for bone regeneration in clinical applications. |
| first_indexed | 2024-03-09T02:16:28Z |
| format | Article |
| id | doaj.art-08bf3cfc142941ea9e51e85eb895e9d0 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-09T02:16:28Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-08bf3cfc142941ea9e51e85eb895e9d02023-12-07T04:08:35ZengWileyAdvanced Science2198-38442023-12-011034n/an/a10.1002/advs.202304190Pearl Powder Hybrid Bioactive Scaffolds from Microfluidic 3D Printing for Bone RegenerationLei Yang0Lu Fan1Xiang Lin2Yunru Yu3Yuanjin Zhao4Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering Southeast University Nanjing 210096 ChinaDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering Southeast University Nanjing 210096 ChinaDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering Southeast University Nanjing 210096 ChinaDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering Southeast University Nanjing 210096 ChinaDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering Southeast University Nanjing 210096 ChinaAbstract The development of bioactive scaffolds by mimicking bone tissue extracellular matrix is promising for bone regeneration. Herein, inspired by the bone tissue composition, a novel pearl powder (PP) hybrid fish gelatin methacrylate (GelMa) hydrogel scaffold loaded with vascular endothelial growth factor (VEGF) for bone regeneration is presented. With the help of microfluidic‐assisted 3D printing technology, the composition and structure of the hybrid scaffold can be accurately controlled to meet clinical requirements. The combination of fish skin GelMa and PP also endowed the hybrid scaffold with good biocompatibility, cell adhesion, and osteogenic differentiation ability. Moreover, the controlled release of VEGF enables the scaffold to promote angiogenesis. Thus, the bone regeneration in the proposed scaffolds could be accelerated under the synergic effect of osteogenesis and angiogenesis, which has been proved in the rat skull defect model. These features indicate that the PP hybrid scaffolds will be an ideal candidate for bone regeneration in clinical applications.https://doi.org/10.1002/advs.2023041903D printingbone regenerationgrowth factormicrofluidicspearl powder |
| spellingShingle | Lei Yang Lu Fan Xiang Lin Yunru Yu Yuanjin Zhao Pearl Powder Hybrid Bioactive Scaffolds from Microfluidic 3D Printing for Bone Regeneration Advanced Science 3D printing bone regeneration growth factor microfluidics pearl powder |
| title | Pearl Powder Hybrid Bioactive Scaffolds from Microfluidic 3D Printing for Bone Regeneration |
| title_full | Pearl Powder Hybrid Bioactive Scaffolds from Microfluidic 3D Printing for Bone Regeneration |
| title_fullStr | Pearl Powder Hybrid Bioactive Scaffolds from Microfluidic 3D Printing for Bone Regeneration |
| title_full_unstemmed | Pearl Powder Hybrid Bioactive Scaffolds from Microfluidic 3D Printing for Bone Regeneration |
| title_short | Pearl Powder Hybrid Bioactive Scaffolds from Microfluidic 3D Printing for Bone Regeneration |
| title_sort | pearl powder hybrid bioactive scaffolds from microfluidic 3d printing for bone regeneration |
| topic | 3D printing bone regeneration growth factor microfluidics pearl powder |
| url | https://doi.org/10.1002/advs.202304190 |
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