The Role of Human Aldo-Keto Reductases (AKRs) in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH-catechols and PAH o-Quinones

The Role of Human Aldo-Keto Reductases (AKRs) in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH-catechols and PAH o-Quinones

Polycyclic aromatic hydrocarbons (PAH) are ubiquitous environmental pollutants. They are procarcinogens requiring metabolic activation to elicit their deleterious effects. Aldo-keto reductases (AKR) catalyze the oxidation of proximate carcinogenic PAH trans-dihydrodiols to yield electrophilic and re...

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Bibliographic Details
Main Authors:	Li eZhang, Yi eJin, Meng eHuang, Trevor M. Penning
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2012-11-01
Series:	Frontiers in Pharmacology
Subjects:	aldo-keto reductases polycyclic aromatic hydrocarbons o-quinones Conjugation reactions Phase II metabolism Redox cycling
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00193/full

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