Human non-CpG methylation patterns display both tissue-specific and inter-individual differences suggestive of underlying function

Human non-CpG methylation patterns display both tissue-specific and inter-individual differences suggestive of underlying function

DNA methylation (DNAm) in mammals is mostly examined within the context of CpG dinucleotides. Non-CpG DNAm is also widespread across the human genome, but the functional relevance, tissue-specific disposition, and inter-individual variability has not been widely studied. Our aim was to examine non-C...

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Bibliographic Details
Main Authors: Philip Titcombe, Robert Murray, Matthew Hewitt, Elie Antoun, Cyrus Cooper, Hazel M Inskip, Joanna D Holbrook, Keith M Godfrey, Karen Lillycrop, Mark Hanson, Sheila J Barton
Format: Article
Language:English
Published: Taylor & Francis Group 2022-06-01
Series:Epigenetics
Subjects:
dna methylation
non-cpg
methylation
cpg
chh
chg
cat
cac
cnn
hierarchical clustering analysis
hca
cluster
tissue-specific
individual-specific
methylation patterns
human
umbilical cord
umbilical cord blood
muscle
peripheral blood
comparison
Online Access:http://dx.doi.org/10.1080/15592294.2021.1950990

Internet

http://dx.doi.org/10.1080/15592294.2021.1950990

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