Effect of Peroxisome Proliferator-Activated Receptor Agonists on Serum Inflammatory Markers in Diabetic Rats
Background: Inflammation had a key role in several pathological conditions including atherosclerosis. Previous studies indicated that the proxisome proliferator-activated receptors (PPAR) are involved in numerous physiological and pathological conditions. The aim of this study was to investigate the...
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| Format: | Article |
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Isfahan University of Medical Sciences
2014-05-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/3250 |
| _version_ | 1797728312775147520 |
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| author | Majid Khazaei Zoya Tahergorabi Ensieh Salehi |
| author_facet | Majid Khazaei Zoya Tahergorabi Ensieh Salehi |
| author_sort | Majid Khazaei |
| collection | DOAJ |
| description | Background: Inflammation had a key role in several pathological conditions including atherosclerosis. Previous studies indicated that the proxisome proliferator-activated receptors (PPAR) are involved in numerous physiological and pathological conditions. The aim of this study was to investigate the effect of PPAR agonists including PPARα (fenofibrate), PPARβ/δ (GW0742), PPARγ (rosiglitazone) and pan PPAR (bezafibrate) administration on serum high-sensitive C-reactive protein (hsCRP) and interleukine-6 (IL-6) in male diabetic rats.
Methods: The male Wistar rats were received streptozotocin for induction of type I diabetes. Then, they were randomly divided into five groups: diabetic, diabetic + fenofibrate (100 mg/kg/day; gavage), diabetic + GW0742 (1 mg/kg/day, subcutaneous), diabetic + rosiglitazone (8 mg/kg/day; gavage) and diabetic + bezafibrate (400mg/kg/day; gavage). After 21 days, the serum levels of hsCRP and IL-6 were measured using the enzyme-linked immunosorbent assay (ELISA) kits.
Findings: Administration of different PPAR agonists did not alter serum hsCRP and IL-6 concentrations in diabetic animals.
Conclusion: It seems that changes of serum inflammatory markers are not responsible for effects of PPARs agonist in atherosclerosis process and other mechanisms should be studied. |
| first_indexed | 2024-03-12T11:12:13Z |
| format | Article |
| id | doaj.art-08c1731b0fb9467cb18d5f372a4f47e2 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T11:12:13Z |
| publishDate | 2014-05-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-08c1731b0fb9467cb18d5f372a4f47e22023-09-02T02:30:59ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2014-05-01322772562611555Effect of Peroxisome Proliferator-Activated Receptor Agonists on Serum Inflammatory Markers in Diabetic RatsMajid Khazaei0Zoya Tahergorabi1Ensieh Salehi2Associate Professor, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant professor, Department of Physiology, School of Medicine, Birjand University of Medical Sciences, Birjand, IranDepartment of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: Inflammation had a key role in several pathological conditions including atherosclerosis. Previous studies indicated that the proxisome proliferator-activated receptors (PPAR) are involved in numerous physiological and pathological conditions. The aim of this study was to investigate the effect of PPAR agonists including PPARα (fenofibrate), PPARβ/δ (GW0742), PPARγ (rosiglitazone) and pan PPAR (bezafibrate) administration on serum high-sensitive C-reactive protein (hsCRP) and interleukine-6 (IL-6) in male diabetic rats. Methods: The male Wistar rats were received streptozotocin for induction of type I diabetes. Then, they were randomly divided into five groups: diabetic, diabetic + fenofibrate (100 mg/kg/day; gavage), diabetic + GW0742 (1 mg/kg/day, subcutaneous), diabetic + rosiglitazone (8 mg/kg/day; gavage) and diabetic + bezafibrate (400mg/kg/day; gavage). After 21 days, the serum levels of hsCRP and IL-6 were measured using the enzyme-linked immunosorbent assay (ELISA) kits. Findings: Administration of different PPAR agonists did not alter serum hsCRP and IL-6 concentrations in diabetic animals. Conclusion: It seems that changes of serum inflammatory markers are not responsible for effects of PPARs agonist in atherosclerosis process and other mechanisms should be studied.http://jims.mui.ac.ir/index.php/jims/article/view/3250Inflammatory factorInterleukineC-reactive proteinDiabetes |
| spellingShingle | Majid Khazaei Zoya Tahergorabi Ensieh Salehi Effect of Peroxisome Proliferator-Activated Receptor Agonists on Serum Inflammatory Markers in Diabetic Rats مجله دانشکده پزشکی اصفهان Inflammatory factor Interleukine C-reactive protein Diabetes |
| title | Effect of Peroxisome Proliferator-Activated Receptor Agonists on Serum Inflammatory Markers in Diabetic Rats |
| title_full | Effect of Peroxisome Proliferator-Activated Receptor Agonists on Serum Inflammatory Markers in Diabetic Rats |
| title_fullStr | Effect of Peroxisome Proliferator-Activated Receptor Agonists on Serum Inflammatory Markers in Diabetic Rats |
| title_full_unstemmed | Effect of Peroxisome Proliferator-Activated Receptor Agonists on Serum Inflammatory Markers in Diabetic Rats |
| title_short | Effect of Peroxisome Proliferator-Activated Receptor Agonists on Serum Inflammatory Markers in Diabetic Rats |
| title_sort | effect of peroxisome proliferator activated receptor agonists on serum inflammatory markers in diabetic rats |
| topic | Inflammatory factor Interleukine C-reactive protein Diabetes |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/3250 |
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