The Induction of Hypothyroidism during Gestation Decreases Outer Hair Cell Motility in Rat Offspring
Introduction Perinatal hypothyroidism has a negative repercussion on the development and maturation of auditory system function. However, its long-term effect on auditory function remains unsettled. Objective To evaluate the effect of prenatal hypothyroidism on the auditory function of ad...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2022-10-01
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| Series: | International Archives of Otorhinolaryngology |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1745856 |
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| author | Priscila Feliciano de Oliveira Beatriz Barros Santos Trindade Paloma Fonseca Martins Reis Tâmara Figueiredo do Carmo Santos Julio Cesar Santana Alves Demetrius Silva de Santana Daniel Badauê-Passos Jr |
| author_facet | Priscila Feliciano de Oliveira Beatriz Barros Santos Trindade Paloma Fonseca Martins Reis Tâmara Figueiredo do Carmo Santos Julio Cesar Santana Alves Demetrius Silva de Santana Daniel Badauê-Passos Jr |
| author_sort | Priscila Feliciano de Oliveira |
| collection | DOAJ |
| description | Introduction Perinatal hypothyroidism has a negative repercussion on the development and maturation of auditory system function. However, its long-term effect on auditory function remains unsettled.
Objective To evaluate the effect of prenatal hypothyroidism on the auditory function of adult offspring in rats.
Methods Pregnant Wistar rats were given the antithyroid drug methimazole (0.02% -1-methylimidazole-2-thiol– MMI) in drinking water, ad libitum, from gestational day (GD) 9 to postnatal day 15 (PND15). Anesthetized offspring from MMI-treated dams (OMTD) and control rats were evaluated by tympanometry, distortion product otoacoustic emission (DPOAE), and auditory brainstem response (ABR) at PNDs 30, 60, 90, and 120.
Results Our data demonstrated no middle ear dysfunction, with the OMTD compliance lower than that of the control group. The DPOAE revealed the absence of outer hair cells function, and the ABR showed normal integrity of neural auditory pathways up to brainstem level in the central nervous system. Furthermore, in the OMTD group, hearing loss was characterized by a higher electrophysiological threshold.
Conclusion Our data suggest that perinatal hypothyroidism leads to irreversible damage to cochlear function in offspring. |
| first_indexed | 2024-04-13T10:41:02Z |
| format | Article |
| id | doaj.art-08c183e478c2410c8d6667467b1cbd1e |
| institution | Directory Open Access Journal |
| issn | 1809-9777 1809-4864 |
| language | English |
| last_indexed | 2024-04-13T10:41:02Z |
| publishDate | 2022-10-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | International Archives of Otorhinolaryngology |
| spelling | doaj.art-08c183e478c2410c8d6667467b1cbd1e2022-12-22T02:49:56ZengThieme Revinter Publicações Ltda.International Archives of Otorhinolaryngology1809-97771809-48642022-10-012604e712e71710.1055/s-0042-1745856The Induction of Hypothyroidism during Gestation Decreases Outer Hair Cell Motility in Rat OffspringPriscila Feliciano de Oliveira0Beatriz Barros Santos Trindade1Paloma Fonseca Martins Reis2Tâmara Figueiredo do Carmo Santos3Julio Cesar Santana Alves4Demetrius Silva de Santana5Daniel Badauê-Passos Jr6Department of Health Sciences, Universidade Federal de Sergipe, São Cristóvão, SE, BrazilDepartment of Speech, Language and Hearing, Universidade Federal de Sergipe, São Cristóvão, SE, BrazilDepartment of Speech, Language and Hearing, Universidade Federal de Sergipe, São Cristóvão, SE, BrazilDepartment of Speech, Language and Hearing, Universidade Federal de Sergipe, São Cristóvão, SE, BrazilDepartment of Health Sciences, Universidade Federal de Sergipe, São Cristóvão, SE, BrazilDepartment of Physiology, Universidade Federal de Sergipe, São Cristóvão, SE, BrazilDepartment of Physiology, Universidade Federal de Sergipe, São Cristóvão, SE, BrazilIntroduction Perinatal hypothyroidism has a negative repercussion on the development and maturation of auditory system function. However, its long-term effect on auditory function remains unsettled. Objective To evaluate the effect of prenatal hypothyroidism on the auditory function of adult offspring in rats. Methods Pregnant Wistar rats were given the antithyroid drug methimazole (0.02% -1-methylimidazole-2-thiol– MMI) in drinking water, ad libitum, from gestational day (GD) 9 to postnatal day 15 (PND15). Anesthetized offspring from MMI-treated dams (OMTD) and control rats were evaluated by tympanometry, distortion product otoacoustic emission (DPOAE), and auditory brainstem response (ABR) at PNDs 30, 60, 90, and 120. Results Our data demonstrated no middle ear dysfunction, with the OMTD compliance lower than that of the control group. The DPOAE revealed the absence of outer hair cells function, and the ABR showed normal integrity of neural auditory pathways up to brainstem level in the central nervous system. Furthermore, in the OMTD group, hearing loss was characterized by a higher electrophysiological threshold. Conclusion Our data suggest that perinatal hypothyroidism leads to irreversible damage to cochlear function in offspring.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1745856congenital hypothyroidismcochleahearing loss |
| spellingShingle | Priscila Feliciano de Oliveira Beatriz Barros Santos Trindade Paloma Fonseca Martins Reis Tâmara Figueiredo do Carmo Santos Julio Cesar Santana Alves Demetrius Silva de Santana Daniel Badauê-Passos Jr The Induction of Hypothyroidism during Gestation Decreases Outer Hair Cell Motility in Rat Offspring International Archives of Otorhinolaryngology congenital hypothyroidism cochlea hearing loss |
| title | The Induction of Hypothyroidism during Gestation Decreases Outer Hair Cell Motility in Rat Offspring |
| title_full | The Induction of Hypothyroidism during Gestation Decreases Outer Hair Cell Motility in Rat Offspring |
| title_fullStr | The Induction of Hypothyroidism during Gestation Decreases Outer Hair Cell Motility in Rat Offspring |
| title_full_unstemmed | The Induction of Hypothyroidism during Gestation Decreases Outer Hair Cell Motility in Rat Offspring |
| title_short | The Induction of Hypothyroidism during Gestation Decreases Outer Hair Cell Motility in Rat Offspring |
| title_sort | induction of hypothyroidism during gestation decreases outer hair cell motility in rat offspring |
| topic | congenital hypothyroidism cochlea hearing loss |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1745856 |
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