Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy
The prevalence of food allergy has been steadily rising worldwide with the highest incidence noted among younger children, and increasingly recognized as a growing public concern. The first known ingestion of foods often causes allergic reaction, suggesting that sensitization of offspring with food...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.01933/full |
| _version_ | 1818288414985814016 |
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| author | Takashi Fujimura Takashi Fujimura Shelly Zing Chin Lum Yuka Nagata Yuka Nagata Seiji Kawamoto Michiko K. Oyoshi Michiko K. Oyoshi |
| author_facet | Takashi Fujimura Takashi Fujimura Shelly Zing Chin Lum Yuka Nagata Yuka Nagata Seiji Kawamoto Michiko K. Oyoshi Michiko K. Oyoshi |
| author_sort | Takashi Fujimura |
| collection | DOAJ |
| description | The prevalence of food allergy has been steadily rising worldwide with the highest incidence noted among younger children, and increasingly recognized as a growing public concern. The first known ingestion of foods often causes allergic reaction, suggesting that sensitization of offspring with food allergens may occur during pregnancy and/or through breastfeeding. This creates a milieu that shapes the neonatal immune responses to these allergens. However, the effects of maternal allergen exposure and maternal sensitization with allergens on development of allergies in offspring remain controversial. This review discusses recent advances from human data in our understanding of how maternal factors, namely, food allergens, allergen-specific immunoglobulins, cytokines, genetics, and environmental factors transferred during pregnancy or breastfeeding influence offspring allergies and how such effects may be applicable to food allergy. Based on information obtained from mouse models of asthma and food allergy, the review also dissects the mechanisms by which maternal factors, including the impact of immune complexes, transforming growth factor-β, vitamin A, and regulatory T-cell responses, contribute to the induction of neonatal tolerance vs. development of allergic responses to maternally transferred allergens. |
| first_indexed | 2024-12-13T01:56:01Z |
| format | Article |
| id | doaj.art-08c1ed669be943eb9c061846e99f6909 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T01:56:01Z |
| publishDate | 2019-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-08c1ed669be943eb9c061846e99f69092022-12-22T00:03:23ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-08-011010.3389/fimmu.2019.01933466809Influences of Maternal Factors Over Offspring Allergies and the Application for Food AllergyTakashi Fujimura0Takashi Fujimura1Shelly Zing Chin Lum2Yuka Nagata3Yuka Nagata4Seiji Kawamoto5Michiko K. Oyoshi6Michiko K. Oyoshi7Division of Immunology, Boston Children's Hospital, Boston, MA, United StatesHiroshima Research Center for Healthy Aging (HiHA), Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi-Hiroshima, JapanDivision of Immunology, Boston Children's Hospital, Boston, MA, United StatesDivision of Immunology, Boston Children's Hospital, Boston, MA, United StatesDivision of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama, JapanHiroshima Research Center for Healthy Aging (HiHA), Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi-Hiroshima, JapanDivision of Immunology, Boston Children's Hospital, Boston, MA, United StatesDepartment of Pediatrics, Harvard Medical School, Boston, MA, United StatesThe prevalence of food allergy has been steadily rising worldwide with the highest incidence noted among younger children, and increasingly recognized as a growing public concern. The first known ingestion of foods often causes allergic reaction, suggesting that sensitization of offspring with food allergens may occur during pregnancy and/or through breastfeeding. This creates a milieu that shapes the neonatal immune responses to these allergens. However, the effects of maternal allergen exposure and maternal sensitization with allergens on development of allergies in offspring remain controversial. This review discusses recent advances from human data in our understanding of how maternal factors, namely, food allergens, allergen-specific immunoglobulins, cytokines, genetics, and environmental factors transferred during pregnancy or breastfeeding influence offspring allergies and how such effects may be applicable to food allergy. Based on information obtained from mouse models of asthma and food allergy, the review also dissects the mechanisms by which maternal factors, including the impact of immune complexes, transforming growth factor-β, vitamin A, and regulatory T-cell responses, contribute to the induction of neonatal tolerance vs. development of allergic responses to maternally transferred allergens.https://www.frontiersin.org/article/10.3389/fimmu.2019.01933/fullallergenasthmabreast milkfood allergyimmune complexesimmunoglobulins |
| spellingShingle | Takashi Fujimura Takashi Fujimura Shelly Zing Chin Lum Yuka Nagata Yuka Nagata Seiji Kawamoto Michiko K. Oyoshi Michiko K. Oyoshi Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy Frontiers in Immunology allergen asthma breast milk food allergy immune complexes immunoglobulins |
| title | Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy |
| title_full | Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy |
| title_fullStr | Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy |
| title_full_unstemmed | Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy |
| title_short | Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy |
| title_sort | influences of maternal factors over offspring allergies and the application for food allergy |
| topic | allergen asthma breast milk food allergy immune complexes immunoglobulins |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.01933/full |
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