Mechanism of Action and Clinical Potential of Fingolimod for the Treatment of Stroke
Fingolimod (FTY720) is an orally bio-available immunomodulatory drug currently approved by the FDA for the treatment of multiple sclerosis. Currently, there is a significant interest in the potential benefits of FTY720 on stroke outcomes. FTY720 and the sphingolipid signaling pathway it modulates ha...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-08-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00139/full |
| _version_ | 1819058859586617344 |
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| author | Wentao Li Haoliang Xu Fernando Daniel Testai |
| author_facet | Wentao Li Haoliang Xu Fernando Daniel Testai |
| author_sort | Wentao Li |
| collection | DOAJ |
| description | Fingolimod (FTY720) is an orally bio-available immunomodulatory drug currently approved by the FDA for the treatment of multiple sclerosis. Currently, there is a significant interest in the potential benefits of FTY720 on stroke outcomes. FTY720 and the sphingolipid signaling pathway it modulates has a ubiquitous presence in the central nervous system and both rodent models and pilot clinical trials seem to indicate that the drug may improve overall functional recovery in different stroke subtypes. Although the precise mechanisms behind these beneficial effects are yet unclear, there is evidence that FTY720 has a role in regulating cerebrovascular responses, blood brain barrier permeability, and cell survival in the event of cerebrovascular insult. In this article, we critically review the data obtained from the latest laboratory findings and clinical trials involving both ischemic and hemorrhagic stroke, and attempt to form a cohesive picture of FTY720’s mechanisms of action in stroke |
| first_indexed | 2024-12-21T14:01:54Z |
| format | Article |
| id | doaj.art-08c2c17c73824ccbb94a46bdceb6a7fd |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-21T14:01:54Z |
| publishDate | 2016-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-08c2c17c73824ccbb94a46bdceb6a7fd2022-12-21T19:01:20ZengFrontiers Media S.A.Frontiers in Neurology1664-22952016-08-01710.3389/fneur.2016.00139213058Mechanism of Action and Clinical Potential of Fingolimod for the Treatment of StrokeWentao Li0Haoliang Xu1Fernando Daniel Testai2University of Illinois at ChicagoUniversity of Illinois at ChicagoUniversity of Illinois at ChicagoFingolimod (FTY720) is an orally bio-available immunomodulatory drug currently approved by the FDA for the treatment of multiple sclerosis. Currently, there is a significant interest in the potential benefits of FTY720 on stroke outcomes. FTY720 and the sphingolipid signaling pathway it modulates has a ubiquitous presence in the central nervous system and both rodent models and pilot clinical trials seem to indicate that the drug may improve overall functional recovery in different stroke subtypes. Although the precise mechanisms behind these beneficial effects are yet unclear, there is evidence that FTY720 has a role in regulating cerebrovascular responses, blood brain barrier permeability, and cell survival in the event of cerebrovascular insult. In this article, we critically review the data obtained from the latest laboratory findings and clinical trials involving both ischemic and hemorrhagic stroke, and attempt to form a cohesive picture of FTY720’s mechanisms of action in strokehttp://journal.frontiersin.org/Journal/10.3389/fneur.2016.00139/fullStrokeNeuroprotectionhemorrhagic strokeischemic strokeSphingosine-1-phosphatevascular endothelium |
| spellingShingle | Wentao Li Haoliang Xu Fernando Daniel Testai Mechanism of Action and Clinical Potential of Fingolimod for the Treatment of Stroke Frontiers in Neurology Stroke Neuroprotection hemorrhagic stroke ischemic stroke Sphingosine-1-phosphate vascular endothelium |
| title | Mechanism of Action and Clinical Potential of Fingolimod for the Treatment of Stroke |
| title_full | Mechanism of Action and Clinical Potential of Fingolimod for the Treatment of Stroke |
| title_fullStr | Mechanism of Action and Clinical Potential of Fingolimod for the Treatment of Stroke |
| title_full_unstemmed | Mechanism of Action and Clinical Potential of Fingolimod for the Treatment of Stroke |
| title_short | Mechanism of Action and Clinical Potential of Fingolimod for the Treatment of Stroke |
| title_sort | mechanism of action and clinical potential of fingolimod for the treatment of stroke |
| topic | Stroke Neuroprotection hemorrhagic stroke ischemic stroke Sphingosine-1-phosphate vascular endothelium |
| url | http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00139/full |
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