Association between serum ferritin and uric acid levels and nonalcoholic fatty liver disease in the Chinese population
Background The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Accumulating evidence suggests that serum ferritin and uric acid (UA) are strongly associated with the risk of NAFLD, but no consensus has been reached. Objective We sought to demonstrate the association b...
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PeerJ Inc.
2023-10-01
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| Online Access: | https://peerj.com/articles/16267.pdf |
| _version_ | 1827598661879595008 |
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| author | Fangli Zhou Xiaoli He Dan Liu Yan Ye Haoming Tian Li Tian |
| author_facet | Fangli Zhou Xiaoli He Dan Liu Yan Ye Haoming Tian Li Tian |
| author_sort | Fangli Zhou |
| collection | DOAJ |
| description | Background The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Accumulating evidence suggests that serum ferritin and uric acid (UA) are strongly associated with the risk of NAFLD, but no consensus has been reached. Objective We sought to demonstrate the association between serum ferritin, UA levels, and NAFLD risk in a large cohort study. Methods We separated 2,049 patients into non-NAFLD and NAFLD groups. The NAFLD group had four subgroups based on serum ferritin and four subgroups based on UA quartile levels. We used binary logistic regression to evaluate the correlation between serum ferritin, UA, and NAFLD. Additionally, an area under the curve (AUC) of receiver operating characteristic analysis (ROC) was used to predict the diagnostic value of combined serum ferritin and UA for NAFLD. Results Serum ferritin and UA levels were higher in the NAFLD group compared with the non-NAFLD group. Serum lipid and liver transaminase concentrations were elevated with the increase of serum ferritin and UA. The logistic regression results showed an independent correlation between serum ferritin, UA, and NAFLD. In the NAFLD group, the AUC value of serum ferritin and UA was 0.771. Conclusions Increased serum ferritin and UA levels are independent risk factors for NAFLD. Increased serum UA is a stronger risk factor for NAFLD than elevated serum ferritin. Serum ferritin and UA can be important predictors of NAFLD risk. |
| first_indexed | 2024-03-09T03:57:10Z |
| format | Article |
| id | doaj.art-08c2c71e7d5e4be6b03b956bd1d96b44 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T03:57:10Z |
| publishDate | 2023-10-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-08c2c71e7d5e4be6b03b956bd1d96b442023-12-03T14:17:39ZengPeerJ Inc.PeerJ2167-83592023-10-0111e1626710.7717/peerj.16267Association between serum ferritin and uric acid levels and nonalcoholic fatty liver disease in the Chinese populationFangli Zhou0Xiaoli He1Dan Liu2Yan Ye3Haoming Tian4Li Tian5West China Hospital, Sichuan University, Department of Endocrinology, Chengdu, Sichuan, ChinaWest China Hospital, Sichuan University, Department of Outpatient, Chengdu, Sichuan, ChinaWest China Hospital, Sichuan University, Department of Endocrinology, Chengdu, Sichuan, ChinaWest China Fourth Hospital, Sichuan University, Department of Gastroenterology, Chengdu, Sichuan, ChinaWest China Hospital, Sichuan University, Department of Endocrinology, Chengdu, Sichuan, ChinaWest China Hospital, Sichuan University, Laboratory of Endocrinology and Metabolism, Department of Endocrinology, Chengdu, Sichuan, ChinaBackground The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Accumulating evidence suggests that serum ferritin and uric acid (UA) are strongly associated with the risk of NAFLD, but no consensus has been reached. Objective We sought to demonstrate the association between serum ferritin, UA levels, and NAFLD risk in a large cohort study. Methods We separated 2,049 patients into non-NAFLD and NAFLD groups. The NAFLD group had four subgroups based on serum ferritin and four subgroups based on UA quartile levels. We used binary logistic regression to evaluate the correlation between serum ferritin, UA, and NAFLD. Additionally, an area under the curve (AUC) of receiver operating characteristic analysis (ROC) was used to predict the diagnostic value of combined serum ferritin and UA for NAFLD. Results Serum ferritin and UA levels were higher in the NAFLD group compared with the non-NAFLD group. Serum lipid and liver transaminase concentrations were elevated with the increase of serum ferritin and UA. The logistic regression results showed an independent correlation between serum ferritin, UA, and NAFLD. In the NAFLD group, the AUC value of serum ferritin and UA was 0.771. Conclusions Increased serum ferritin and UA levels are independent risk factors for NAFLD. Increased serum UA is a stronger risk factor for NAFLD than elevated serum ferritin. Serum ferritin and UA can be important predictors of NAFLD risk.https://peerj.com/articles/16267.pdfNonalcoholic fatty liver diseaseFerritinUric acid |
| spellingShingle | Fangli Zhou Xiaoli He Dan Liu Yan Ye Haoming Tian Li Tian Association between serum ferritin and uric acid levels and nonalcoholic fatty liver disease in the Chinese population PeerJ Nonalcoholic fatty liver disease Ferritin Uric acid |
| title | Association between serum ferritin and uric acid levels and nonalcoholic fatty liver disease in the Chinese population |
| title_full | Association between serum ferritin and uric acid levels and nonalcoholic fatty liver disease in the Chinese population |
| title_fullStr | Association between serum ferritin and uric acid levels and nonalcoholic fatty liver disease in the Chinese population |
| title_full_unstemmed | Association between serum ferritin and uric acid levels and nonalcoholic fatty liver disease in the Chinese population |
| title_short | Association between serum ferritin and uric acid levels and nonalcoholic fatty liver disease in the Chinese population |
| title_sort | association between serum ferritin and uric acid levels and nonalcoholic fatty liver disease in the chinese population |
| topic | Nonalcoholic fatty liver disease Ferritin Uric acid |
| url | https://peerj.com/articles/16267.pdf |
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