A ligand-independent integrin β1 mechanosensory complex guides spindle orientation
During cell division, the orientation of the mitotic spindle is sensitive to forces exerted on the cell cortex. Here Petridou and Skourides show that such cues are sensed by a mechanosensory complex established on force activated integrin β1 independent of ligand binding.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10899 |
| _version_ | 1818842031892463616 |
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| author | Nicoletta I. Petridou Paris A. Skourides |
| author_facet | Nicoletta I. Petridou Paris A. Skourides |
| author_sort | Nicoletta I. Petridou |
| collection | DOAJ |
| description | During cell division, the orientation of the mitotic spindle is sensitive to forces exerted on the cell cortex. Here Petridou and Skourides show that such cues are sensed by a mechanosensory complex established on force activated integrin β1 independent of ligand binding. |
| first_indexed | 2024-12-19T04:35:31Z |
| format | Article |
| id | doaj.art-08c31188016642ab98f554081dcd7e8b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:35:31Z |
| publishDate | 2016-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-08c31188016642ab98f554081dcd7e8b2022-12-21T20:35:46ZengNature PortfolioNature Communications2041-17232016-03-017111510.1038/ncomms10899A ligand-independent integrin β1 mechanosensory complex guides spindle orientationNicoletta I. Petridou0Paris A. Skourides1Department of Biological Sciences, University of Cyprus, UniversityDepartment of Biological Sciences, University of Cyprus, UniversityDuring cell division, the orientation of the mitotic spindle is sensitive to forces exerted on the cell cortex. Here Petridou and Skourides show that such cues are sensed by a mechanosensory complex established on force activated integrin β1 independent of ligand binding.https://doi.org/10.1038/ncomms10899 |
| spellingShingle | Nicoletta I. Petridou Paris A. Skourides A ligand-independent integrin β1 mechanosensory complex guides spindle orientation Nature Communications |
| title | A ligand-independent integrin β1 mechanosensory complex guides spindle orientation |
| title_full | A ligand-independent integrin β1 mechanosensory complex guides spindle orientation |
| title_fullStr | A ligand-independent integrin β1 mechanosensory complex guides spindle orientation |
| title_full_unstemmed | A ligand-independent integrin β1 mechanosensory complex guides spindle orientation |
| title_short | A ligand-independent integrin β1 mechanosensory complex guides spindle orientation |
| title_sort | ligand independent integrin β1 mechanosensory complex guides spindle orientation |
| url | https://doi.org/10.1038/ncomms10899 |
| work_keys_str_mv | AT nicolettaipetridou aligandindependentintegrinb1mechanosensorycomplexguidesspindleorientation AT parisaskourides aligandindependentintegrinb1mechanosensorycomplexguidesspindleorientation AT nicolettaipetridou ligandindependentintegrinb1mechanosensorycomplexguidesspindleorientation AT parisaskourides ligandindependentintegrinb1mechanosensorycomplexguidesspindleorientation |