A ligand-independent integrin β1 mechanosensory complex guides spindle orientation

During cell division, the orientation of the mitotic spindle is sensitive to forces exerted on the cell cortex. Here Petridou and Skourides show that such cues are sensed by a mechanosensory complex established on force activated integrin β1 independent of ligand binding.

Bibliographic Details
Main Authors: Nicoletta I. Petridou, Paris A. Skourides
Format: Article
Language:English
Published: Nature Portfolio 2016-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10899